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Mitonafide
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Catalog No. T25817Cas No. 54824-17-8
Alias NSC-300288, NSC300288, NSC 300288
Mitonafide (NSC-300288) suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.
Mitonafide
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Purity: 99.89%
Catalog No. T25817Alias NSC-300288, NSC300288, NSC 300288Cas No. 54824-17-8
Mitonafide (NSC-300288) suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $30 | In Stock | In Stock | |
| 2 mg | $40 | In Stock | In Stock | |
| 5 mg | $64 | In Stock | In Stock | |
| 10 mg | $97 | In Stock | In Stock | |
| 25 mg | $198 | In Stock | In Stock | |
| 50 mg | $328 | In Stock | In Stock | |
| 100 mg | $537 | In Stock | In Stock | |
| 200 mg | $767 | In Stock | In Stock | |
| 500 mg | $1,150 | In Stock | - | |
| 1 mL x 10 mM (in DMSO) | $71 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.89%
Appearance:Solid
Color:White
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Product Introduction
Mitonafide AI Summary
Mitonafide exhibits a variety of potent bioactivities, particularly related to DNA binding and antiproliferative effects against cancer cell lines. It has demonstrated DNA binding affinity comparable to ethidium bromide, with a C50 value of 11.0 µM and a dissociation constant (KD) of log 5.16. Furthermore, it shows significant cytotoxicity against multiple human cancer cell lines, including HT-29 with an IC50 of 600.0 nM, A549, SK-MEL-2, HL-60, and MCF-7, along with notable inhibition of cell growth in these lines. The compound's binding affinity, as measured by melting temperature changes, ranges with the highest Delta Tm of 17.2°C for specific DNA sequences, suggesting a role in stabilizing these structures. This compound also exhibits antiproliferative activity under hypoxic conditions in A375 and V79 cells. Additionally, it shows effective anticancer activity in xenografted mice models, with substantial inhibition of tumor growth at various doses. Mitonafide also disrupts specific molecular pathways and targets, including Nrf2 and Importin beta complex formation, indicating broad bioactivity and potential as an antitumor agent..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Mitonafide (NSC-300288) suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent. |
| Synonyms | NSC-300288, NSC300288, NSC 300288 |
| Molecular Weight | 313.31 |
| Formula | C16H15N3O4 |
| Cas No. | 54824-17-8 |
| Smiles | CN(C)CCN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O |
| Relative Density. | 1.384g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 13 mg/mL (41.49 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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