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Glucagon (1-29), bovine, human, porcine

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Catalog No. T15389Cas No. 16941-32-5
Alias Glucagon

Glucagon (1-29), bovine, human, porcine is a hormone produced by pancreatic α-cells with glucagon activity, which promotes glycogenolysis and gluconeogenesis, and is used in the study of obesity and diabetes.

Glucagon (1-29), bovine, human, porcine
Other Forms of Glucagon (1-29), bovine, human, porcine:

Glucagon (1-29), bovine, human, porcine

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Purity: 99.91%
Catalog No. T15389Alias GlucagonCas No. 16941-32-5
Glucagon (1-29), bovine, human, porcine is a hormone produced by pancreatic α-cells with glucagon activity, which promotes glycogenolysis and gluconeogenesis, and is used in the study of obesity and diabetes.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$6637-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.91%
Appearance:Solid
Color:White
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COA MS HPLC

Product Introduction

Bioactivity
Description
Glucagon (1-29), bovine, human, porcine is a hormone produced by pancreatic α-cells with glucagon activity, which promotes glycogenolysis and gluconeogenesis, and is used in the study of obesity and diabetes.
In vitro
Glucagon (1-29), bovine, human, porcine binds to its receptor Gcgr and activates the cAMP-PKA signaling pathway, which in turn promotes hepatic gluconeogenesis and triggers hyperglycemia. In addition, Glucagon (1-29), bovine, human, porcine stimulates hepatic production of kisspeptin1 and gluconeogenesis. [1]
Glucagon (1-29), bovine, human, porcine inhibits the expression of CYP7A1 mRNA in human primary hepatocytes at a concentration of 100 nM and increases the phosphorylation of HNF4α. increased the phosphorylation level of HNF4α. [3]
In vivo
A low dose of 20 μg/kg Glucagon (1-29), bovine, human, porcine increased blood glucose but did not stimulate insulin secretion in mice fed in a normal environment. A high dose of 1 mg/kg Glucagon (1-29), bovine, human, porcine lowered blood glucose and stimulated insulin secretion in mice fed in a normal environment compared to the PBS control. [4]
SynonymsGlucagon
Chemical Properties
Molecular Weight3482.75
FormulaC153H225N43O49S
Cas No.16941-32-5
SmilesC([C@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC5=CN=CN5)N)=O)CO)=O)CCC(N)=O)=O)=O)[C@@H](C)O)=O)=O)[C@@H](C)O)=O)CO)=O)CC(O)=O)=O)=O)CO)=O)CCCCN)=O)=O)CC(C)C)=O)CC(O)=O)=O)CO)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)C)=O)CCC(N)=O)=O)CC(O)=O)=O)=O)[C@H](C)C)=O)CCC(N)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)CC(N)=O)=O)CCSC)=O)CC(C)C)=O)C=6C=7C(NC6)=CC=CC7
Relative Density.1.31g/cm3
SequenceH-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH
Sequence ShortHSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 1 mg/mL (0.29 mM), Sonication is recommended.
H2O: 4 mg/mL (1.15 mM), when pH is adjusted to 2 with HCl. Sonication is recommmended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Porcine glucagon(1-29), bovine, human, porcineGlucagonReceptorGlucagon ReceptorGlucagon , bovine, human, porcineGlucagon (129), bovine, human, porcineGlucagon (1 29), bovine, human, porcineGCGR
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