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BI-9627

Name: BI-9627
Brand: TargetMol
SKU: T14566
Rating: 4.5 (1 reviews)

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Catalog No. T14566Cas No. 1204329-34-9

BI-9627 is a selective and potent sodium hydrogen exchange isomer 1 (NHE1) inhibitor.BI-9627 partially reverses the effects of DMA with IC50 values of 6 and 31 nM in the intracellular pH recovery (pHi) and human platelet lysis assays.BI-9627 is often used as a negative control for BI-0054, which can be used for the study of ischemia-reperfusion injury in isolated hearts. BI-9627 is often used as a negative control for BI-0054 and can be used to study ischemia-reperfusion injury in isolated hearts.

BI-9627

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Catalog No. T14566Cas No. 1204329-34-9

Pack Size	Price	Availability
2 mg	$52	5 days
10 mg	$164	7-10 days
50 mg	$540	7-10 days

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Product Introduction

Bioactivity

Description

Targets&IC50

NHE1 (intracellular pH recovery assay):6 nM, NHE1 (human platelet swelling assay):31 nM

Chemical Properties

Molecular Weight	356.34
Formula	C₁₆H₁₉F₃N₄O₂
Cas No.	1204329-34-9
Relative Density.	1.42 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (224.50 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8063 mL	14.0315 mL	28.0631 mL	140.3154 mL
5 mM	0.5613 mL	2.8063 mL	5.6126 mL	28.0631 mL
10 mM	0.2806 mL	1.4032 mL	2.8063 mL	14.0315 mL
20 mM	0.1403 mL	0.7016 mL	1.4032 mL	7.0158 mL
50 mM	0.0561 mL	0.2806 mL	0.5613 mL	2.8063 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	1.4032 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc