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Methylmalonic acid

Name: Methylmalonic acid
Brand: TargetMol
SKU: T4817
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4817Cas No. 516-05-2

Alias NSC 25201, MMA, Methylpropanedioic acid, Methylmalonate, Isosuccinic acid

Methylmalonic acid is an indicator of vitamin B-12 deficiency in cancer patients.Methylmalonic acid is a competitive succinate dehydrogenase inhibitor.

Methylmalonic acid

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Purity: 98%

Catalog No. T4817Alias NSC 25201, MMA, Methylpropanedioic acid, Methylmalonate, Isosuccinic acidCas No. 516-05-2

Methylmalonic acid is an indicator of vitamin B-12 deficiency in cancer patients.Methylmalonic acid is a competitive succinate dehydrogenase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$33	In Stock	In Stock
2 g	$40	-	In Stock
5 g	$54	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Color:White

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COA

Product Introduction

Methylmalonic acid AI Summary

Methylmalonic acid exhibits a diverse range of bioactivities with various potencies across multiple targets. It functions as an inhibitor of AmpC Beta-Lactamase (5623.4 nM), JMJD2A-Tudor Domain (79432.8 nM), HIV-1 Budding via PTAP/TSG101 interaction (56234.1 nM), Histone Lysine Methyltransferase G9a (10000.0 nM), the Ran-regulated importin-beta cargo complex dissociation (290.9 nM), Hepatitis C Virus (HCV) (35481.3 nM), and Pin1 (39810.7 nM). Additionally, it delays the death of the malarial parasite plastid (1471.6 nM) and induces DNA re-replication in SW480 colon adenocarcinoma cells (631.0 nM). It also acts as an antagonist of the gsp mutation associated with Fibrous Dysplasia/McCune-Albright Syndrome (25118.9 nM). Furthermore, Methylmalonic acid inhibits mouse serine racemase with an IC50 value of 1850000.0 nM, using L-serine as the substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Methylmalonic acid is an indicator of vitamin B-12 deficiency in cancer patients.Methylmalonic acid is a competitive succinate dehydrogenase inhibitor.
Synonyms	NSC 25201, MMA, Methylpropanedioic acid, Methylmalonate, Isosuccinic acid

Chemical Properties

Molecular Weight	118.09
Formula	C₄H₆O₄
Cas No.	516-05-2
Smiles	C(C(O)=O)(C(O)=O)C
Relative Density.	1.45

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 73.8 mg/mL (624.95 mM), Sonication is recommended.

H2O: 100 mg/mL (846.81 mM), Sonication is recommended.

Ethanol: 100 mg/mL (846.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (16.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	8.4681 mL	42.3406 mL	84.6812 mL	423.4059 mL
5 mM	1.6936 mL	8.4681 mL	16.9362 mL	84.6812 mL
10 mM	0.8468 mL	4.2341 mL	8.4681 mL	42.3406 mL
20 mM	0.4234 mL	2.1170 mL	4.2341 mL	21.1703 mL
50 mM	0.1694 mL	0.8468 mL	1.6936 mL	8.4681 mL
100 mM	0.0847 mL	0.4234 mL	0.8468 mL	4.2341 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc