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XY101

Name: XY101
Brand: TargetMol
SKU: T13362
Price: 79 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13362Cas No. 2349368-16-5

XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).

XY101

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Purity: 99.83%

Catalog No. T13362Cas No. 2349368-16-5

XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$79	In Stock	In Stock
5 mg	$173	In Stock	In Stock
10 mg	$298	In Stock	In Stock
25 mg	$475	In Stock	In Stock
50 mg	$678	In Stock	In Stock
100 mg	$912	In Stock	In Stock
500 mg	$1,780	-	In Stock
1 mL x 10 mM (in DMSO)	$215	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:Orange

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).
Targets&IC50	RORγ:(kd)380 nM , RORγ:30 nM
In vitro	XY101 effectively inhibits cell growth, colony formation and expression of androgen receptor (AR), AR-V7 and prostate specific antigen (PSA)[1].
In vivo	XY101 demonstrates substantial antitumor effects, including inhibition of tumor growth, throughout the treatment period and is well-tolerated, evidenced by the absence of significant body weight loss[1].

Chemical Properties

Molecular Weight	563.48
Formula	C₂₅H₂₀F₇NO₄S
Cas No.	2349368-16-5
Smiles	CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)-c2ccc(cc2F)C(O)(C(F)(F)F)C(F)(F)F)cc1
Relative Density.	1.439 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (399.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (8.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7747 mL	8.8734 mL	17.7469 mL	88.7343 mL
5 mM	0.3549 mL	1.7747 mL	3.5494 mL	17.7469 mL
10 mM	0.1775 mL	0.8873 mL	1.7747 mL	8.8734 mL
20 mM	0.0887 mL	0.4437 mL	0.8873 mL	4.4367 mL
50 mM	0.0355 mL	0.1775 mL	0.3549 mL	1.7747 mL
100 mM	0.0177 mL	0.0887 mL	0.1775 mL	0.8873 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc