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Anti-CD30/TNFRSF8 Antibody-APC (9F649) is a APC-conjugated Mouse antibody targeting CD30/TNFRSF8. Anti-CD30/TNFRSF8 Antibody-APC (9F649) can be used in FCM.
Description | Anti-CD30/TNFRSF8 Antibody-APC (9F649) is a APC-conjugated Mouse antibody targeting CD30/TNFRSF8. Anti-CD30/TNFRSF8 Antibody-APC (9F649) can be used in FCM. |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 9F649 |
Reactivity | Human |
Verified Activity | Profile of anti-Human TNFRSF8 (CD30) reactivity on K562 cells analyzed by flow cytometry. |
Application | FCM |
Recommended Dose | 10 μl/Test, 0.1 mg/ml |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD30 / TNFRSF8 (rh CD30 / TNFRSF8; TMPY-01827; NP_001234.2; Met 1-Lys 379) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
Purification | Protein A |
Appearance | Liquid |
Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
Research Background | CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor (TNFR) superfamily. CD30 protein is expressed by activated, but not resting, T and B cells. CD30 can regulate proliferation of lymphocytes and may also play an important role in human immunodeficiency virus replication. As a regulator of apoptosis, CD30 protein induces cell death or proliferation, depending on the cell type, and has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. CD30 protein expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs), and CD30 is also linked to leukocytes in patients with chronic inflammatory diseases, including lupus erythematosus, asthma, rheumatoid arthritis and atopic dermatitis (AD).Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
Conjucates | APC |
Others Formats | Unconjugated/FITC/PE |
Antibody Types Available | 4 |
Immunogen | Recombinant Human CD30 / TNFRSF8 protein (TMPY-01827) |
Antigen Species | Human |
Biology Area | Cancer Drug Targets |
Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
Transport | Shipping with blue ice. |
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