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TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His)
(Synonyms: tumor necrosis factor receptor superfamily, member 1b) Copy Product InfoSynonyms: tumor necrosis factor receptor superfamily, member 1b
Catalog No. TMPY-03101 Copy Product Info
Purity: 98.3%
TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is XP_005544817.1&NP_001253134.1.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $75 | - | In Stock | |
| 10 µg | $118 | - | In Stock | |
| 20 µg | $196 | - | In Stock | |
| 50 µg | $386 | - | In Stock | |
| 100 µg | $620 | 7-10 days | 7-10 days | |
| 200 µg | $995 | 7-10 days | 7-10 days | |
| 500 µg | $1,860 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.3%
Appearance:Lyophilized powder
Color:White
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Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | 1.Immobilized Recombinant Cynomolgus/Rhesus TNFR2/CD120b/TNFRSF1B Protein (His Tag) (Cat#TMPY-03101) at 5 μg/mL (100 μL/well) can bind Recombinant Human TNF-alpha/TNFA Protein, Biotinylated (Cat#TMPY-05237), the EC50 is 4.8 ng/mL (Routinely tested). 2.Immobilized Recombinant Human TNF-alpha/TNFA Protein, Biotinylated (Cat#TMPY-05237) at 1 μg/mL (100 μl/well) on Streptavidin precoated (5 μg/mL, 100 μL/well) can bind Recombinant Cynomolgus/Rhesus TNFR2/CD120b/TNFRSF1B Protein (His Tag) (Cat#TMPY-03101), the EC50 is 1-5 ng/mL (QC tested). |
| Description | TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is XP_005544817.1&NP_001253134.1. |
| Species | Cynomolgus,Rhesus |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | XP_005544817.1&NP_001253134.1 |
| Construction | A DNA sequence encoding the cynomolgus / rhesus TNFRSF1B (XP_005544817.1/NP_001253134.1) (Met1-Asp257) was expressed, fused with a polyhistidine tag at the C-terminus. Cynomolgus and Rhesus TNFRSF1B sequences are identical. Predicted N terminal: Leu 23 |
| Protein Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.  , |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| Synonyms | tumor necrosis factor receptor superfamily, member 1b |
| Research Background | Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 26.5 kDa (predicted); 38 kDa (reducing conditions) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His) chemical structure | TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Rhesus, Recombinant (His) molecular weight
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