Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Naphthofluorescein (Naphthafluorescein) is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhibits glycolytic activity in cancer cells and macrophages without showing significant in vitro cytotoxicity or in vivo side effects. Naphthofluorescein is also a fluorescent pH-sensitive probe for functional Cherenkov imaging.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 42.00 | |
25 mg | In stock | $ 80.00 | |
50 mg | In stock | $ 125.00 |
Description | Naphthofluorescein (Naphthafluorescein) is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhibits glycolytic activity in cancer cells and macrophages without showing significant in vitro cytotoxicity or in vivo side effects. Naphthofluorescein is also a fluorescent pH-sensitive probe for functional Cherenkov imaging. |
In vitro | Naphthofluorescein (compound 19) (0-10 μM; 24 h; HT1080 cells) significantly suppresses the HIF-1 reporter activity in a concentration-dependent manner.[1] |
In vivo | Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily; 5 days followed by 2 days off for 2 weeks; Male C57BL/6J mice) significantly suppresses the tumour growth of subcutaneously injected E0771 cells and significantly attenuates tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, Naphthofluorescein suppresses tumour growth in human cancer cells in an FIH-1-dependent manner and does not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells. At the same time, Neither showed weight loss or apparent histological abnormalities in the lung, liver, and kidney nor caused severe adverse effects for at least 2 weeks in mice.[1] |
Synonyms | Naphthafluorescein |
Molecular Weight | 432.42 |
Formula | C28H16O5 |
CAS No. | 61419-02-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 2 mg/mL
DMSO: 100 mg/mL (231.26 mM), Sonication is recommended.
DMF: 10 mg/mL
DMF:PBS (pH 7) (1:10): 0.09 mg/mL
You can also refer to dose conversion for different animals. More
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Naphthofluorescein 61419-02-1 Angiogenesis Chromatin/Epigenetic HIF Naphthafluorescein inhibitor inhibit