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Frataxin-IN-1

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Catalog No. T86470Cas No. 102616-64-8

Frataxin-IN-1 is an inhibitor of the mitochondrial protein Frataxin, with an inhibitory concentration (IC 50) value of 45 μM. Compound (+)-11 is utilized in research focused on Friedreich's ataxia (FRDA), a neurodegenerative disorder associated with impaired mitochondrial function and iron-sulfur cluster biogenesis.

Frataxin-IN-1

Frataxin-IN-1

🥰Excellent
Catalog No. T86470Cas No. 102616-64-8
Frataxin-IN-1 is an inhibitor of the mitochondrial protein Frataxin, with an inhibitory concentration (IC 50) value of 45 μM. Compound (+)-11 is utilized in research focused on Friedreich's ataxia (FRDA), a neurodegenerative disorder associated with impaired mitochondrial function and iron-sulfur cluster biogenesis.
Pack SizePriceAvailabilityQuantity
1 mg$293In Stock
5 mg$722In Stock
10 mg$987In Stock
25 mg$1,520In Stock
50 mg$1,980In Stock
100 mg$2,500In Stock
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Product Introduction

Bioactivity
Description
Frataxin-IN-1 is an inhibitor of the mitochondrial protein Frataxin, with an inhibitory concentration (IC 50) value of 45 μM. Compound (+)-11 is utilized in research focused on Friedreich's ataxia (FRDA), a neurodegenerative disorder associated with impaired mitochondrial function and iron-sulfur cluster biogenesis.
Targets&IC50
Frataxin:45 μM
Chemical Properties
Molecular Weight373.4
FormulaC20H23NO6
Cas No.102616-64-8
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: <1 mg/mL (insoluble)
DMSO: 100 mg/mL (267.81 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6781 mL13.3905 mL26.7809 mL133.9047 mL
5 mM0.5356 mL2.6781 mL5.3562 mL26.7809 mL
10 mM0.2678 mL1.3390 mL2.6781 mL13.3905 mL
20 mM0.1339 mL0.6695 mL1.3390 mL6.6952 mL
50 mM0.0536 mL0.2678 mL0.5356 mL2.6781 mL
100 mM0.0268 mL0.1339 mL0.2678 mL1.3390 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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