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Anti-Phospho-4EBP1/2/3 (Thr45) Antibody (2T82)
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Catalog No. TMAC-00023
Anti-Phospho-4EBP1/2/3 (Thr45) Antibody (2T82) is a Mouse antibody targeting Phospho-4EBP1/2/3 (Thr45). Anti-Phospho-4EBP1/2/3 (Thr45) Antibody (2T82) can be used in WB,IP,IF.
Anti-Phospho-4EBP1/2/3 (Thr45) Antibody (2T82)
Anti-Phospho-4EBP1/2/3 (Thr45) Antibody (2T82)
😃Good
Catalog No. TMAC-00023
Anti-Phospho-4EBP1/2/3 (Thr45) Antibody (2T82) is a Mouse antibody targeting Phospho-4EBP1/2/3 (Thr45). Anti-Phospho-4EBP1/2/3 (Thr45) Antibody (2T82) can be used in WB,IP,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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Chemical Properties
| Description | Anti-Phospho-4EBP1/2/3 (Thr45) Antibody (2T82) is a Mouse antibody targeting Phospho-4EBP1/2/3 (Thr45). Anti-Phospho-4EBP1/2/3 (Thr45) Antibody (2T82) can be used in WB,IP,IF. |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:100-1000; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The multisubunit eukaryotic translation initiation factor (eIF) 4F recruits 40S ribosomal subunits to the 5' end of mRNA. The eIF4F subunit eIF4E interacts directly with the mRNA 5' cap structure. Assembly of the eIF4F complex is inhibited by a family of repressor polypeptides, the eIF4E-binding proteins (4E-BPs). 4E-BP1 (also known as PHAS-1) normally binds eIF4E, inhibiting cap-dependent translation. Hyper-phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. The PI3-kinase/Akt pathway and the FRAP/mTOR kinase regulate 4E-BP1. 4E-BP1 is phosphorylated in vivo on multiple residues and phosphorylation by FRAP/mTOR on Threonine 37 and Threonine 46 of human 4E-BP1 may prime it for sub-sequent phosphorylation at sites including Serine 65 and Threonine 70. The corresponding rat residues include Threonine 36, Threonine 45, Serine 64 and Threonine 69. In vitro, 4E-BP1 is also phosphorylated by ataxia telangiectasia (ATM) at human Serine 112 (rat Serine 111) in response to an increase in insulin levels. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide |
| Antigen Species | Peptide |
| Gene ID |
| Molecular Weight | Theoretical: 21 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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