Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells. This compound can be activated by NQO1 to effectively release podophyllotoxin, thereby killing tumor cells. In HepG2 xenograft models, Antitumor agent-67 significantly inhibits cancer growth with minimal toxicity [1].
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Description | Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells. This compound can be activated by NQO1 to effectively release podophyllotoxin, thereby killing tumor cells. In HepG2 xenograft models, Antitumor agent-67 significantly inhibits cancer growth with minimal toxicity [1]. |
In vitro | Antitumor agent-67 (compound 3) exhibits antiproliferative effects on a range of cells including HepG2, A549, LO2, HepG2/Hyp, A549/Hyp, and A549/T, demonstrating IC50 values of 84 ± 9 μM, 100 ± 19 μM, 312 ± 34 μM, 113 ± 13 μM, 185 ± 24 μM, and 197 ± 29 μM, respectively [1]. |
Molecular Weight | 809.85 |
Formula | C45H47NO13 |
CAS No. | 2820146-10-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Antitumor agent-67 2820146-10-7 inhibitor inhibit