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Anti-Phospho-Dnmt1 (Ser154) Polyclonal Antibody
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Catalog No. TMAB-10604
Anti-Phospho-Dnmt1 (Ser154) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Dnmt1 (Ser154). Anti-Phospho-Dnmt1 (Ser154) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Anti-Phospho-Dnmt1 (Ser154) Polyclonal Antibody
Anti-Phospho-Dnmt1 (Ser154) Polyclonal Antibody
😃Good
Catalog No. TMAB-10604
Anti-Phospho-Dnmt1 (Ser154) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Dnmt1 (Ser154). Anti-Phospho-Dnmt1 (Ser154) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-Dnmt1 (Ser154) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Dnmt1 (Ser154). Anti-Phospho-Dnmt1 (Ser154) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Dog,Pig,Cow,Sheep) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human Dnmt1 around the phosphorylation site of Ser153 |
| Antigen Species | Human |
| Gene Name | DNMT1 |
| Gene ID | |
| Protein Name | DNA(cytosine-5)-methyltransferase 1 |
| Uniprot ID | |
| Function | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. |
| Molecular Weight | Theoretical: 178 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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