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Theophylline-platinum(IV) prodrug-1

Name: Theophylline-platinum(IV) prodrug-1
Brand: TargetMol
SKU: T211939
Rating: 4.5 (1 reviews)

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Theophylline-platinum(IV) prodrug-1 is a PARP-1 inhibitor. It enhances DNA damage, ROS generation, mitochondrial dysfunction, apoptosis, and S-phase arrest in SKOV3-BRCA1-KD cells while reducing invasion and metastasis. Additionally, it exhibits strong antitumor activity in SKOV3-BRCA1-KD xenograft tumor models. This compound is used for ovarian cancer research.

Theophylline-platinum
(IV) prodrug-1

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Theophylline-platinum(IV) prodrug-1 is a PARP-1 inhibitor. It enhances DNA damage, ROS generation, mitochondrial dysfunction, apoptosis, and S-phase arrest in SKOV3-BRCA1-KD cells while reducing invasion and metastasis. Additionally, it exhibits strong antitumor activity in SKOV3-BRCA1-KD xenograft tumor models. This compound is used for ovarian cancer research.
In vitro	Theophylline-platinum(IV) prodrug-1 effectively inhibits the proliferation of various cell lines, including SKOV3 (IC 50 = 0.13 μM), SKOV3-BRCA1-KD (IC 50 = 0.1 μM), A549 (IC 50 = 0.31 μM), A549-BRCA1-KD (IC 50 = 0.18 μM), MCF-7 (IC 50 = 0.10 μM), MCF-7-BRCA1-KD (IC 50 = 0.04 μM), MDA-MB-231 (IC 50 = 0.08 μM), IOSE-80 (IC 50 = 0.18 μM), and SI (IC 50 = 18 μM) when applied at concentrations of 10 to 10^-3 μM for 72 hours. This compound also induces DNA damage in SKOV3 and SKOV3-BRCA1-KD cells at a concentration of 10 μM over 6 hours. Additionally, at concentrations ranging from 0.5 to 2 μM for 24 hours, it prompts reactive oxygen species (ROS) generation, disrupts mitochondrial membrane potential, causes cell cycle arrest, and initiates apoptosis in the same cell lines. Furthermore, at 0.5 μM for 24 hours, it inhibits invasion and metastasis in SKOV3 and SKOV3-BRCA1-KD cells.
In vivo	Theophylline-platinum(IV) prodrug-1 (Compound 4) exhibits outstanding antitumor activity in the SKOV3-BRCA1-KD xenograft tumor model, administered intravenously at 2.5 mg/kg every three days over a total of six doses.

Storage & Solubility Information

Storage	Keep away from direct sunlight,The compound is unstable in solution. Please use soon Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: Soluble, DMSO inactivates the activity of Theophylline-platinum(IV) prodrug-1.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Theophylline-platinum(IV) prodrug-1 in vivo | Theophylline-platinum(IV) prodrug-1 in vitro