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MMP-12 Inhibitor

Name: MMP-12 Inhibitor
Brand: TargetMol
SKU: T60083
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T60083Cas No. 1258003-93-8

MMP-12 Inhibitor is a selective inhibitor of MMP-12 with IC50s of 2, 160, 320, and 22.3 nM for human, mouse, rat, and sheep MMP-12.

MMP-12 Inhibitor

🥰Excellent

Purity: 99.96%

Catalog No. T60083Cas No. 1258003-93-8

MMP-12 Inhibitor is a selective inhibitor of MMP-12 with IC50s of 2, 160, 320, and 22.3 nM for human, mouse, rat, and sheep MMP-12.

Pack Size	Price	Availability
1 mg	$195	In Stock
5 mg	$448	In Stock
10 mg	$675	In Stock
25 mg	$1,154	In Stock
50 mg	$1,729	In Stock
100 mg	$2,595	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.96%

ee:97.54%

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COA CSFC ORP LCMS HNMR

Product Introduction

Bioactivity

Description	MMP-12 Inhibitor is a selective inhibitor of MMP-12 with IC50s of 2, 160, 320, and 22.3 nM for human, mouse, rat, and sheep MMP-12.
In vitro	MMP-12 Inhibitor shows weaker activity against human MMP-3, MMP-13, and MMP-14 with IC50s of 351, 120, and 1100 nM[1].
In vivo	In mice, MMP-12 Inhibitor (5 mg/kg, p.o.) effectively alleviates rhMMP-12-induced pulmonary inflammatory response by more than 50%[1].

Chemical Properties

Molecular Weight	420.44
Formula	C₁₉H₂₀N₂O₇S
Cas No.	1258003-93-8
Smiles	N(C(OC)=O)C=1C=C2C=3C(OC2=CC1)=CC(S(N[C@H](C(C)C)C(O)=O)(=O)=O)=CC3
Relative Density.	1.440 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (118.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3785 mL	11.8923 mL	23.7846 mL	118.9230 mL
5 mM	0.4757 mL	2.3785 mL	4.7569 mL	23.7846 mL
10 mM	0.2378 mL	1.1892 mL	2.3785 mL	11.8923 mL
20 mM	0.1189 mL	0.5946 mL	1.1892 mL	5.9462 mL
50 mM	0.0476 mL	0.2378 mL	0.4757 mL	2.3785 mL
100 mM	0.0238 mL	0.1189 mL	0.2378 mL	1.1892 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc