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(R)-MMP408

Name: (R)-MMP408
Brand: TargetMol
SKU: T60083
Price: 185 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60083Cas No. 1258003-93-8

Alias MMP-12 Inhibitor

(R)-MMP-408 is an isomer of MMP-408, which is an effective MMP-12 inhibitor with an IC₅₀ of 2 nM against human MMP-12. (R)-MMP 408 can influence the epithelial-mesenchymal transition (EMT) process in nasal epithelial cells and is suitable for use in research on chronic obstructive pulmonary disease (COPD) and chronic sinusitis.

(R)-MMP408

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Purity: 99.96%

Catalog No. T60083Alias MMP-12 InhibitorCas No. 1258003-93-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$185	-	In Stock
5 mg	$426	-	In Stock
10 mg	$641	-	In Stock
25 mg	$1,080	-	In Stock
50 mg	$1,460	-	In Stock
100 mg	$1,970	-	In Stock
1 mL x 10 mM (in DMSO)	$440	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.96%

ee:97.54%

Appearance:Solid

Color:White

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COA CSFC ORP LCMS HNMR

Product Introduction

Bioactivity

Description	(R)-MMP-408 is an isomer of MMP-408, which is an effective MMP-12 inhibitor with an IC₅₀ of 2 nM against human MMP-12. (R)-MMP 408 can influence the epithelial-mesenchymal transition (EMT) process in nasal epithelial cells and is suitable for use in research on chronic obstructive pulmonary disease (COPD) and chronic sinusitis.
In vitro	MMP-408 shows weaker activity against human MMP-3, MMP-13, and MMP-14 with IC50s of 351, 120, and 1100 nM[1].
In vivo	In mice, MMP-408 (5 mg/kg, p.o.) effectively alleviates rhMMP-12-induced pulmonary inflammatory response by more than 50%[1].
Synonyms	MMP-12 Inhibitor

Chemical Properties

Molecular Weight	420.44
Formula	C₁₉H₂₀N₂O₇S
Cas No.	1258003-93-8
Smiles	N(C(OC)=O)C=1C=C2C=3C(OC2=CC1)=CC(S(N[C@H](C(C)C)C(O)=O)(=O)=O)=CC3
Relative Density.	1.440 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (356.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3785 mL	11.8923 mL	23.7846 mL	118.9230 mL
5 mM	0.4757 mL	2.3785 mL	4.7569 mL	23.7846 mL
10 mM	0.2378 mL	1.1892 mL	2.3785 mL	11.8923 mL
20 mM	0.1189 mL	0.5946 mL	1.1892 mL	5.9462 mL
50 mM	0.0476 mL	0.2378 mL	0.4757 mL	2.3785 mL
100 mM	0.0238 mL	0.1189 mL	0.2378 mL	1.1892 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc