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Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody

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Catalog No. TMAC-01769

Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC1 (Ser421). Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody can be used in WB.

Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody

Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody

😃Good
Catalog No. TMAC-01769
Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC1 (Ser421). Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2177-10 days
100 μL$3187-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC1 (Ser421). Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of Serine 421 (E-F-S(p)-D-S) derived from Human HDAC1
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 62 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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