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Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody
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Catalog No. TMAC-01769
Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC1 (Ser421). Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody can be used in WB.
Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody
Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody
😃Good
Catalog No. TMAC-01769
Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC1 (Ser421). Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $217 | 7-10 days | |
| 100 μL | $318 | 7-10 days |
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| Description | Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC1 (Ser421). Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human |
| Application | |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of Serine 421 (E-F-S(p)-D-S) derived from Human HDAC1 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 62 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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