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HNHA

Name: HNHA
Brand: TargetMol
SKU: T21806
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21806Cas No. 926908-04-5

HNHA is an inhibitor of HDAC.

HNHA

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🥰Excellent

Purity: 98.04%

Catalog No. T21806Cas No. 926908-04-5

HNHA is an inhibitor of HDAC.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$76	In Stock	In Stock
10 mg	$129	In Stock	In Stock
25 mg	$278	In Stock	In Stock
50 mg	$446	In Stock	In Stock
100 mg	$645	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.04%

Appearance:solid

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	HNHA is an inhibitor of HDAC.
Targets&IC50	HDAC:100 nM
In vitro	Treatment of cells with HNHA could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of HT1080 cell invasion. HNHA was able to inhibit in-vitro HDAC enzyme activity as well as proliferation of human fibrosarcoma cells (HT1080).
In vivo	Several HDAC inhibitors, including MS-27-275 and a hydroxyamide-based HDAC inhibitors such as SAHA have been investigated extensively and shown to inhibit tumor growth in vivo.

Chemical Properties

Molecular Weight	303.42
Formula	C₁₇H₂₁NO₂S
Cas No.	926908-04-5
Smiles	ONC(=O)CCCCCCSc1ccc2ccccc2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 15 mg/mL (49.44 mM), Sonication is recommended.

DMSO: 15 mg/mL (49.44 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2958 mL	16.4788 mL	32.9576 mL	164.7881 mL
5 mM	0.6592 mL	3.2958 mL	6.5915 mL	32.9576 mL
10 mM	0.3296 mL	1.6479 mL	3.2958 mL	16.4788 mL
20 mM	0.1648 mL	0.8239 mL	1.6479 mL	8.2394 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc