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HNHA

Name: HNHA
Brand: TargetMol
SKU: T21806
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T21806Cas No. 926908-04-5

HNHA is an inhibitor of HDAC.

HNHA

🥰Excellent

Purity: 98.04%

Catalog No. T21806Cas No. 926908-04-5

HNHA is an inhibitor of HDAC.

Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$76	In Stock
10 mg	$137	In Stock
25 mg	$293	In Stock
50 mg	$469	In Stock
100 mg	$673	In Stock
200 mg	$926	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock

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Batch Information

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Purity:98.04%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	HNHA is an inhibitor of HDAC.
Targets&IC50	HDAC:100 nM
In vitro	Treatment of cells with HNHA could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of HT1080 cell invasion. HNHA was able to inhibit in-vitro HDAC enzyme activity as well as proliferation of human fibrosarcoma cells (HT1080).
In vivo	Several HDAC inhibitors, including MS-27-275 and a hydroxyamide-based HDAC inhibitors such as SAHA have been investigated extensively and shown to inhibit tumor growth in vivo.

Chemical Properties

Molecular Weight	303.42
Formula	C₁₇H₂₁NO₂S
Cas No.	926908-04-5
Smiles	ONC(=O)CCCCCCSc1ccc2ccccc2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 15 mg/mL (49.44 mM), Sonication is recommended.

DMSO: 15 mg/mL (49.44 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2958 mL	16.4788 mL	32.9576 mL	164.7881 mL
5 mM	0.6592 mL	3.2958 mL	6.5915 mL	32.9576 mL
10 mM	0.3296 mL	1.6479 mL	3.2958 mL	16.4788 mL
20 mM	0.1648 mL	0.8239 mL	1.6479 mL	8.2394 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc