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Diminazene Aceturate

Name: Diminazene Aceturate
Brand: TargetMol
SKU: T1145
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1145Cas No. 908-54-3

Alias DIZE

Diminazene is a trypanocidal agent.

Diminazene Aceturate

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Purity: 99.58%

Catalog No. T1145Alias DIZECas No. 908-54-3

Diminazene is a trypanocidal agent.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$42	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.58%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Diminazene is a trypanocidal agent.
In vitro	Administering 7 mg/kg, i.m. of Diminazene aceturate effectively clears parasites from the bloodstream of infected dogs. An initial treatment dose of 3.5 mg/kg of Diminazene aceturate significantly alleviates T. evansi infection in horses and mules, with parasites being eliminated from the peripheral blood within 1-7 days and 1-14 days, respectively.
In vivo	Transport of [3H] diminazene is substantially inhibited by pentamidine and adenosine, with Ki values of 0.21 μM and 0.25 μM, respectively. Notably, [3H] diminazene accumulates in yeast cells expressing TbAT1 at a rate of 0.0083 pmol/10^7 cells/s when treated with 2.5 μM of the radioactive compound, and this accumulation is completely suppressed by 1 mM of unlabeled Diminazene Aceturate.
Synonyms	DIZE

Chemical Properties

Molecular Weight	515.52
Formula	C₂₂H₂₉N₉O₆
Cas No.	908-54-3
Smiles	c1(ccc(cc1)/N=N/Nc1ccc(cc1)C(=N)N)C(=N)N.CC(=O)NCC(=O)O.CC(=O)NCC(=O)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 92 mg/mL (178.46 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 1 mg/mL (1.94 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.9398 mL	9.6989 mL	19.3979 mL	96.9894 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.3880 mL	1.9398 mL	3.8796 mL	19.3979 mL
10 mM	0.1940 mL	0.9699 mL	1.9398 mL	9.6989 mL
20 mM	0.0970 mL	0.4849 mL	0.9699 mL	4.8495 mL
50 mM	0.0388 mL	0.1940 mL	0.3880 mL	1.9398 mL
100 mM	0.0194 mL	0.0970 mL	0.1940 mL	0.9699 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc