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CAY10464

Name: CAY10464
Brand: TargetMol
SKU: T84540
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T84540Cas No. 688348-37-0

Alias AHR antagonist 7

CAY10464 (AHR antagonist 7) is a potent AHR antagonist with potential antitumor activity that inhibits CYP1A1 mRNA expression and may be used to study cancer and metabolic diseases.

CAY10464

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Purity: 99.96%

Catalog No. T84540Alias AHR antagonist 7Cas No. 688348-37-0

CAY10464 (AHR antagonist 7) is a potent AHR antagonist with potential antitumor activity that inhibits CYP1A1 mRNA expression and may be used to study cancer and metabolic diseases.

Pack Size	Price	Availability
5 mg	$40	In Stock
10 mg	$64	In Stock
25 mg	$129	In Stock
50 mg	$213	In Stock
100 mg	$318	In Stock
500 mg	$759	In Stock

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Batch Information

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Purity:99.96%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	CAY10464 (AHR antagonist 7) is a potent AHR antagonist with potential antitumor activity that inhibits CYP1A1 mRNA expression and may be used to study cancer and metabolic diseases.
In vitro	In HepG2 cells, the AHR antagonist 7 (CAY10464; 100 nM) reduces CYP1A1 mRNA expression and counteracts the Benzo[a]pyrene-induced suppression of apolipoprotein A-I (apo A-I) gene expression [2].
Synonyms	AHR antagonist 7

Chemical Properties

Molecular Weight	279.16
Formula	C₁₅H₁₂Cl₂O
Cas No.	688348-37-0
Smiles	C(=C/C1=CC(Cl)=CC(Cl)=C1)\C2=CC=C(OC)C=C2
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (71.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5822 mL	17.9109 mL	35.8218 mL	179.1088 mL
5 mM	0.7164 mL	3.5822 mL	7.1644 mL	35.8218 mL
10 mM	0.3582 mL	1.7911 mL	3.5822 mL	17.9109 mL
20 mM	0.1791 mL	0.8955 mL	1.7911 mL	8.9554 mL
50 mM	0.0716 mL	0.3582 mL	0.7164 mL	3.5822 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc