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Ibiglustat (L-Malic acid) (Synonyms: Venglustat (L-Malic acid), SAR402671 (L-Malic acid), Ibiglustat L-Malic a...)

Name: Ibiglustat (L-Malic acid)
Brand: TargetMol
SKU: T11599
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T11599 Copy Product Info

Purity: 99.54%

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Ibiglustat (L-Malic acid) (Ibiglustat L-Malic acid) is a selective, brain-penetrant, and allosteric inhibitor of glucosylceramide synthase. Ibiglustat (L-Malic acid) can be used in studies about PD Parkinson's disease, SRT in Fabry's and Gaucher's.

Ibiglustat (L-Malic acid)

Copy Product Info

🥰Excellent

Catalog No. T11599

Synonyms Venglustat (L-Malic acid), SAR402671 (L-Malic acid), Ibiglustat L-Malic acid, GZ402671 (L-Malic acid)

Cas No. 1629063-78-0

Pack Size	Price	USA Stock	Global Stock
1 mg	$33	-	In Stock
2 mg	$48	-	In Stock
5 mg	$93	-	In Stock
10 mg	$137	-	In Stock
25 mg	$232	-	In Stock
50 mg	$345	-	In Stock
100 mg	$493	-	In Stock
200 mg	$687	-	In Stock
1 mL x 10 mM (in DMSO)	$107	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.54%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Ibiglustat (L-Malic acid) (Ibiglustat L-Malic acid) is a selective, brain-penetrant, and allosteric inhibitor of glucosylceramide synthase. Ibiglustat (L-Malic acid) can be used in studies about PD Parkinson's disease, SRT in Fabry's and Gaucher's.
In vitro	Ibiglustat (L-Malic acid) (1 μM) treated Fabry disease cells are close to the physiological level in untreated WT cells in GL-3 levels. Ibiglustat (L-Malic acid) prevents additional GL-3 accumulation and ameliorates the abundant GL-3 levels in FD cardiomyocytes[4].
Synonyms	Venglustat (L-Malic acid), SAR402671 (L-Malic acid), Ibiglustat L-Malic acid, GZ402671 (L-Malic acid)

Chemical Properties

Molecular Weight	523.57
Formula	C₂₄H₃₀FN₃O₇S
Cas No.	1629063-78-0
Smiles	O[C@@H](CC(O)=O)C(O)=O.CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)c1csc(n1)-c1ccc(F)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (171.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9100 mL	9.5498 mL	19.0996 mL	95.4982 mL
5 mM	0.3820 mL	1.9100 mL	3.8199 mL	19.0996 mL
10 mM	0.1910 mL	0.9550 mL	1.9100 mL	9.5498 mL
20 mM	0.0955 mL	0.4775 mL	0.9550 mL	4.7749 mL
50 mM	0.0382 mL	0.1910 mL	0.3820 mL	1.9100 mL
100 mM	0.0191 mL	0.0955 mL	0.1910 mL	0.9550 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc