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Ibiglustat (L-Malic acid)

Name: Ibiglustat (L-Malic acid)
Brand: TargetMol
SKU: T11599
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11599Cas No. 1629063-78-0

Alias Venglustat (L-Malic acid), SAR402671 (L-Malic acid), Ibiglustat L-Malic acid, GZ402671 (L-Malic acid)

Ibiglustat (L-Malic acid) (Ibiglustat L-Malic acid) is a selective, brain-penetrant, and allosteric inhibitor of glucosylceramide synthase. Ibiglustat (L-Malic acid) can be used in studies about PD Parkinson's disease, SRT in Fabry's and Gaucher's.

Ibiglustat (L-Malic acid)

🥰Excellent

Purity: 99.54%

Catalog No. T11599Alias Venglustat (L-Malic acid), SAR402671 (L-Malic acid), Ibiglustat L-Malic acid, GZ402671 (L-Malic acid)Cas No. 1629063-78-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	-	In Stock
2 mg	$48	-	In Stock
5 mg	$93	-	In Stock
10 mg	$137	-	In Stock
25 mg	$232	-	In Stock
50 mg	$345	-	In Stock
100 mg	$493	-	In Stock
200 mg	$687	-	In Stock
1 mL x 10 mM (in DMSO)	$107	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.54%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ibiglustat (L-Malic acid) (Ibiglustat L-Malic acid) is a selective, brain-penetrant, and allosteric inhibitor of glucosylceramide synthase. Ibiglustat (L-Malic acid) can be used in studies about PD Parkinson's disease, SRT in Fabry's and Gaucher's.
In vitro	Ibiglustat (L-Malic acid) (1 μM) treated Fabry disease cells are close to the physiological level in untreated WT cells in GL-3 levels. Ibiglustat (L-Malic acid) prevents additional GL-3 accumulation and ameliorates the abundant GL-3 levels in FD cardiomyocytes[4].
Synonyms	Venglustat (L-Malic acid), SAR402671 (L-Malic acid), Ibiglustat L-Malic acid, GZ402671 (L-Malic acid)

Chemical Properties

Molecular Weight	523.57
Formula	C₂₄H₃₀FN₃O₇S
Cas No.	1629063-78-0
Smiles	O[C@@H](CC(O)=O)C(O)=O.CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)c1csc(n1)-c1ccc(F)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (171.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9100 mL	9.5498 mL	19.0996 mL	95.4982 mL
5 mM	0.3820 mL	1.9100 mL	3.8199 mL	19.0996 mL
10 mM	0.1910 mL	0.9550 mL	1.9100 mL	9.5498 mL
20 mM	0.0955 mL	0.4775 mL	0.9550 mL	4.7749 mL
50 mM	0.0382 mL	0.1910 mL	0.3820 mL	1.9100 mL
100 mM	0.0191 mL	0.0955 mL	0.1910 mL	0.9550 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc