Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ATB107 hydrochloride is a novel and potent inhibitor of indole-3-glycerol phosphate synthase (IGPS) with a KD of 3 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 169.00 | |
5 mg | In stock | $ 383.00 | |
10 mg | In stock | $ 545.00 | |
25 mg | In stock | $ 878.00 | |
50 mg | In stock | $ 1,190.00 | |
100 mg | In stock | $ 1,630.00 | |
500 mg | In stock | $ 3,260.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 436.00 |
Description | ATB107 hydrochloride is a novel and potent inhibitor of indole-3-glycerol phosphate synthase (IGPS) with a KD of 3 μM. |
In vitro | The minimum inhibitory concentration (MIC) of ATB107 hydrochloride is 0.1 μg/mL for M. tuberculosis H37Ra. ATB107 hydrochloride also has high activity against M. tuberculosis H37Rv, with an MIC of 0.1 μg/mL. All 50 fully susceptible clinical isolates tested are susceptible to ATB107 at 1 μg/mL; of these, 41 (82%) are susceptible to ATB107 at 0.1 μg/mL. The results also show that 67 (83.8%) multidrug-resistant TB (MDR-TB) isolates are susceptible to ATB107 hydrochloride at 1 μg/mL, and 25 (31.3%) isolates are susceptible to ATB107 hydrochloride at 0.1 μg/mL. Results show that the binding ability of ATB107 hydrochloride is well correlated with its concentrations. At the highest concentration of 200 μg/mL, ATB107 hydrochloride can inhibit cell proliferation, with cell survival of about 60%. With the lower concentration of 50 μg/mL, cell survival is more than 80% for ATB107 hydrochloride[1]. |
Synonyms | ATB107 hydrochloride(455325-51-6 Free base) |
Molecular Weight | 428.96 |
Formula | C21H29ClN8 |
CAS No. | T10394L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.29 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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ATB107 hydrochloride T10394L Others ATB107 Hydrochloride ATB 107 Hydrochloride ATB107 hydrochloride(455325-51-6 Free base) ATB-107 Hydrochloride inhibitor inhibit