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Iberdomide

🥰Excellent
Catalog No. T7791Cas No. 1323403-33-3
Alias CC-220

Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).

Iberdomide

Iberdomide

🥰Excellent
Purity: 97.01%
Catalog No. T7791Alias CC-220Cas No. 1323403-33-3
Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$39In StockIn Stock
5 mg$97In StockIn Stock
10 mg$172In StockIn Stock
25 mg$343In StockIn Stock
50 mg$538In StockIn Stock
100 mg$793In StockIn Stock
1 mL x 10 mM (in DMSO)$96In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.01%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
Targets&IC50
Cereblon:60 nM
In vitro
Iberdomide has a greater potency for degrading the CRL4 complex substrates Ikaros and Aiolos (EC50s = 1 and 0.5 nM) but has no degradative activity for GSPT1 or CK1α[1].
SynonymsCC-220
Chemical Properties
Molecular Weight449.5
FormulaC25H27N3O5
Cas No.1323403-33-3
SmilesO(CC1=CC=C(CN2CCOCC2)C=C1)C3=C4C(C(=O)N(C4)[C@@H]5C(=O)NC(=O)CC5)=CC=C3
Relative Density.1.332 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 30 mg/mL (66.74 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.45 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2247 mL11.1235 mL22.2469 mL111.2347 mL
5 mM0.4449 mL2.2247 mL4.4494 mL22.2469 mL
10 mM0.2225 mL1.1123 mL2.2247 mL11.1235 mL
20 mM0.1112 mL0.5562 mL1.1123 mL5.5617 mL
50 mM0.0445 mL0.2225 mL0.4449 mL2.2247 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

U266Thalidomidesub-G1RPM-8226orallymyelomamultipleMM1.SMM1.RligaseLigands for E3 LigaseLigandforE3LigaseLigand for E3 LigaseKMS12PEKMS128MKMS11InhibitorinhibitIberdomideH929G0/G1EJME3 ligase-recruiting MoietyCRBNcereblonCELMoDCC220CC 220Apoptosis
Related Tags: buy Iberdomide | purchase Iberdomide | Iberdomide cost | order Iberdomide | Iberdomide chemical structure | Iberdomide in vitro | Iberdomide formula | Iberdomide molecular weight
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