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Iberdomide

Name: Iberdomide
Brand: TargetMol
SKU: T7791
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7791Cas No. 1323403-33-3

Alias CC-220

Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).

Iberdomide

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Purity: 97.01%

Catalog No. T7791Alias CC-220Cas No. 1323403-33-3

Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).

Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$97	In Stock
10 mg	$172	In Stock
25 mg	$343	In Stock
50 mg	$538	In Stock
100 mg	$793	In Stock
1 mL x 10 mM (in DMSO)	$96	In Stock

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Batch Information

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Purity:97.01%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Iberdomide (CC-220) is a modulator of cereblon( IC50 value of 60 nM in a competitive TR-FRET assay).
Targets&IC50	Cereblon:60 nM
In vitro	Iberdomide has a greater potency for degrading the CRL4 complex substrates Ikaros and Aiolos (EC50s = 1 and 0.5 nM) but has no degradative activity for GSPT1 or CK1α[1].
Synonyms	CC-220

Chemical Properties

Molecular Weight	449.5
Formula	C₂₅H₂₇N₃O₅
Cas No.	1323403-33-3
Smiles	O(CC1=CC=C(CN2CCOCC2)C=C1)C3=C4C(C(=O)N(C4)[C@@H]5C(=O)NC(=O)CC5)=CC=C3
Relative Density.	1.332 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (66.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2247 mL	11.1235 mL	22.2469 mL	111.2347 mL
5 mM	0.4449 mL	2.2247 mL	4.4494 mL	22.2469 mL
10 mM	0.2225 mL	1.1123 mL	2.2247 mL	11.1235 mL
20 mM	0.1112 mL	0.5562 mL	1.1123 mL	5.5617 mL
50 mM	0.0445 mL	0.2225 mL	0.4449 mL	2.2247 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc