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Doxepin hydrochloride

Name: Doxepin hydrochloride
Brand: TargetMol
SKU: T1540
Rating: 4.5 (1 reviews)

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Catalog No. T1540Cas No. 1229-29-4

Alias Toruan, Novoxapin, Doxepin HCl, Aponal

Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.

Doxepin hydrochloride

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Purity: 99.91%

Catalog No. T1540Alias Toruan, Novoxapin, Doxepin HCl, AponalCas No. 1229-29-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 g	$40	Inquiry	Inquiry
2 g	$55	Inquiry	Inquiry
5 g	$89	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Doxepin hydrochloride AI Summary

Doxepin hydrochloride shows antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 1258.93 nM to 7943.28 nM as determined by the SYBR green assay after 72 hours of incubation. Additionally, it exhibits a wide range of bioactivities against several biological targets, including ROR gamma transcriptional activity, Schistosoma Mansoni Peroxiredoxins, cell-membrane permeable IMPase inhibitors, chronic active B-cell receptor signaling, histone lysine methyltransferase G9a, human tyrosyl-DNA phosphodiesterase 1 (TDP1) both with and without CPT, and Marburg Virus cell binding or entry. Moreover, Doxepin hydrochloride inhibits sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 µM, achieving an inhibition rate of 101.82%..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Toruan, Novoxapin, Doxepin HCl, Aponal

Chemical Properties

Molecular Weight	315.84
Formula	C₁₉H₂₂ClNO
Cas No.	1229-29-4
Smiles	Cl.CN(C)CCC=C1c2ccccc2COc2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (189.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1662 mL	15.8308 mL	31.6616 mL	158.3080 mL
5 mM	0.6332 mL	3.1662 mL	6.3323 mL	31.6616 mL
10 mM	0.3166 mL	1.5831 mL	3.1662 mL	15.8308 mL
20 mM	0.1583 mL	0.7915 mL	1.5831 mL	7.9154 mL
50 mM	0.0633 mL	0.3166 mL	0.6332 mL	3.1662 mL
100 mM	0.0317 mL	0.1583 mL	0.3166 mL	1.5831 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc