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Doxepin hydrochloride

Name: Doxepin hydrochloride
Brand: TargetMol
SKU: T1540
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T1540Cas No. 1229-29-4

Alias Toruan, Novoxapin, Doxepin HCl, Aponal

Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.

Doxepin hydrochloride

🥰Excellent

Purity: 99.91%

Catalog No. T1540Alias Toruan, Novoxapin, Doxepin HCl, AponalCas No. 1229-29-4

Pack Size	Price	Availability
1 g	$40	In Stock
2 g	$55	In Stock
5 g	$89	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

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Batch Information

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Purity:99.91%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

Synonyms

Toruan, Novoxapin, Doxepin HCl, Aponal

Chemical Properties

Molecular Weight	315.84
Formula	C₁₉H₂₂ClNO
Cas No.	1229-29-4
Smiles	Cl.CN(C)CCC=C1c2ccccc2COc2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60.00 mg/mL (189.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1662 mL	15.8308 mL	31.6616 mL	158.3080 mL
5 mM	0.6332 mL	3.1662 mL	6.3323 mL	31.6616 mL
10 mM	0.3166 mL	1.5831 mL	3.1662 mL	15.8308 mL
20 mM	0.1583 mL	0.7915 mL	1.5831 mL	7.9154 mL
50 mM	0.0633 mL	0.3166 mL	0.6332 mL	3.1662 mL
100 mM	0.0317 mL	0.1583 mL	0.3166 mL	1.5831 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc