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trans-ACPD

Name: trans-ACPD
Brand: TargetMol
SKU: T3484
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3484Cas No. 67684-64-4

Alias Trans-(±)-ACP, 1-amino-1,3-dicarboxycyclopentane, (±)-trans-ACPD

trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the group I/II mGlu receptors (EC50: 2/15/23/800 μM, mGluR2/1/5/4).

trans-ACPD

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Purity: 99.98%

Catalog No. T3484Alias Trans-(±)-ACP, 1-amino-1,3-dicarboxycyclopentane, (±)-trans-ACPDCas No. 67684-64-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
2 mg	$57	In Stock	In Stock
5 mg	$91	In Stock	In Stock
10 mg	$150	In Stock	In Stock
25 mg	$293	In Stock	In Stock
50 mg	$531	In Stock	In Stock
100 mg	$768	-	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD. trans-ACPD is a selective agonist of the mGluR (metabotropic glutamate receptor); active at the group I/II mGlu receptors (EC50: 2/15/23/800 μM, mGluR2/1/5/4).
Targets&IC50	mGluR2:2μM(EC50), mGluR1:15μM(EC50), mGluR5:23μM(EC50), mGluR4:800 μM(EC50)
In vitro	Excitatory amino acid (EAA) analogues activate receptors linked to increased hydrolysis of phosphoinositides (PIs). In these studies, hippocampal slices from neonatal rats (6-11 days old) characterize the effects of EAA analogues on these receptors. The EC50 value of trans-ACPD is 51 μM, and DL-2-Amino-3-phosphonopropionate (DL-AP3) serves as an equally potent inhibitor of PI hydrolysis induced by ibotenate, quisqualate, and trans-ACPD, with IC50 values ranging from 480 to 850 μM [2].
In vivo	Intrathecal administration of NMDA, kainate, and trans-ACPD, along with the pro-inflammatory cytokines TNF-α or IL-1β, markedly increases biting behavior in mice, a paradigm shift from the control group receiving saline. Pre-systemic intervention with GM at a dosage of 100 mg/kg intraperitoneally notably decreases biting behavior in comparison to saline treatment (10 mL/kg, i.p.), with statistical significance (p<0.001). The efficacy of GM is particularly pronounced against pro-inflammatory cytokines and NMDA, exhibiting inhibition rates of TNF-α (92±7%), IL-1β (91±5%), NMDA (69±1%), and trans-ACPD (71±12%). Conversely, kainate-induced biting responses remain unaffected by GM at the same concentration.
Synonyms	Trans-(±)-ACP, 1-amino-1,3-dicarboxycyclopentane, (±)-trans-ACPD

Chemical Properties

Molecular Weight	173.17
Formula	C₇H₁₁NO₄
Cas No.	67684-64-4
Smiles	NC1(CCC(C1)C(O)=O)C(O)=O
Relative Density.	1.452 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

1eq. NaOH: 50 mM, Sonication is recommended.

H2O: 5 mM, Heating is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/1eq. NaOH

	1mg	5mg	10mg	50mg
1 mM	5.7747 mL	28.8734 mL	57.7467 mL	288.7336 mL
5 mM	1.1549 mL	5.7747 mL	11.5493 mL	57.7467 mL

1eq. NaOH

	1mg	5mg	10mg	50mg
10 mM	0.5775 mL	2.8873 mL	5.7747 mL	28.8734 mL
20 mM	0.2887 mL	1.4437 mL	2.8873 mL	14.4367 mL
50 mM	0.1155 mL	0.5775 mL	1.1549 mL	5.7747 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc