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Cytoskeletal SignalingArp2/3 Complex
Arp2/3 complex is a seven-subunit protein complex that plays a major role in the regulation of the actin cytoskeleton. It is a major component of the actin cytoskeleton and is found in most actin cytoskeleton-containing eukaryotic cells. Two of its subunits, the Actin-Related Proteins ARP2 and ARP3, closely resemble the structure of monomeric actin and serve as nucleation sites for new actin filaments. The complex binds to the sides of existing ("mother") filaments and initiates growth of a new ("daughter") filament at a distinctive 70 degree angle from the mother. Branched actin networks are created as a result of this nucleation of new filaments. The regulation of rearrangements of the actin cytoskeleton is important for processes like cell locomotion, phagocytosis, and intracellular motility of lipid vesicles.
Cytochalasin D
T322922144-77-0
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit
- $239
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Cytochalasin B
T709714930-96-2
Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).
- $68
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SMIFH2
Cited
T23372340316-62-3
SMIFH2 is formin homology 2 (FH2) domains inhibitor.
- $30
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CitedCK-666
T10826442633-00-3
CK-666 is a cell-permeable inhibitor of the actin-related protein Arp2/3 complex, binding to and stabilizing its inactive state, thereby preventing the movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) configuration.
- $34
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Wiskostatin
T2164253449-04-6
Wiskostatin is a selective inhibitor of N-WASP, a ubiquitously expressed member of the Wiskott-Aldrich Syndrome protein (WASp) family that regulates actin polymerization.
- $38
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CK-869
T5860388592-44-7
CK-869, an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor with an IC50 of 7 μM, is a valuable tool for investigating the Arp2/3 complex.
- $33
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Benproperine phosphate
T500719428-14-9
Benproperine phosphate (Pirexyl phosphate) is a cough suppressant.
- $37
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CK-636 Cited
T1820442632-72-6
CK-636 (CK-0944636), an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM) Arp2/3 complex, respectively.
- $30
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CitedDihydrocytochalasin B
T1104239156-67-7
Dihydrocytochalasin B (H2CB) is a cell division inhibitor that prevents cytokinesis, alters cell morphology, disrupts actin structures in Swiss/3T3 mouse fibroblasts, and inhibits DNA synthesis induced by serum growth factors in quiescent cultures. Low doses of H2CB lead to cell rounding and the loss of actin microfilament bundles.
- $282
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Jasplakinolide Cited
T11712102396-24-7
Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin.
- $998
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CitedPhallacidin
T4029826645-35-2
Phallacidin, a phallotoxin family member, targets and binds to F-actin in mushroom toxins.
- $775
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Cytochalasin G
TN1018854874-57-6
Cytochalasin G exhibits reversible inhibition of cytokinesis and also inhibits macrophage phagocytosis and exocytosis, among other biological activities.
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187-1, N-WASP inhibitor TFA
T75777
187-1, N-WASP Inhibitor TFA, a 14-amino acid cyclic peptide, serves as an allosteric inhibitor of the neural Wiskott-Aldrich syndrome protein (N-WASP). This compound effectively suppresses actin assembly triggered by phosphatidylinositol 4,5-bisphosphate (PIP2), exhibiting a potent inhibitory concentration (IC 50) of 2 μM. Furthermore, 187-1, N-WASP Inhibitor TFA inhibits the activation of the Arp2 3 complex by N-WASP, maintaining the protein in its autoinhibited state, ensuring the prevention of its activation.
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187-1, N-WASP inhibitor
TP1977380488-27-7
Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization
- $625
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Latrunculin A
T1572176343-93-6
Latrunculin A is a toxin isolated from the red sea sponge Latrunculia magnifica. Latrunculin A binds to actin monomers and it also inhibits polymerization of actin (Kds: 0.1, 0.4, 4.7 μM, and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin, and G-actin, re
- $2,357
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Cytochalasin L
TN1035279637-87-9
Cytochalasin L possesses reversible biological activities, including the inhibition of cytoplasmic division, as well as the suppression of both endocytosis and exocytosis in phagocytic macrophages.
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CK548
T23892388604-55-5
CK548 is a novel actin-related protein (Arp)2/3 complex inhibitor.
- $1,520
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EG-011
T734982377113-41-0
EG-011, a first-in-class and potent activator of Wiskott-Aldrich syndrome protein (WASP), effectively activates the auto-inhibited form of WASP, leading to strong actin polymerization. This compound demonstrates selective anti-tumor activity in lymphomas.
- $764
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Phalloidin-TRITC
T41056915013-10-4
Phalloidin-TRITC is a TRITC labeled, red fluorescence probe for F-actin . Phalloidin, bound to actin filaments, reacts covalently with amino acids Glu-llT, Met-ll9, and Met355, which are very close to the nucleotide binding site.
- $1,600
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19-O-Acetylchaetoglobosin A
T3560950939-69-0
19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, K., Natori, S., et al.Structure-activity relationship of thirty-nine cytochalasans observed in the effects on cellular structures and cellular events and on actin polymerization in vitroJ. Pharmacobiodyn.8(11)906-916(1985)
- $288
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LKKTETQ
T40570476014-70-7
LKKTETQ, a peptide segment within thymosin β 4, constitutes the protein's active site responsible for actin binding, cell migration, and wound healing.
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Cytochalasin F
TN1003336084-18-1
Cytochalasin F reversibly inhibits cytokinesis and possesses various biological activities including the inhibition of macrophage endocytosis and exocytosis.
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Cytochalasin M
TN995279648-73-0
Cytochalasin M exhibits various biological activities, including reversible inhibition of cytoplasmic division and the suppression of both endocytosis and exocytosis in macrophages.
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Latrunculins A
T32588122876-48-6
Latrunculins A is a novel marine toxin, disrupts microfilament organization in cultured cells.
- $5,720
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