Shopping Cart

Your shopping cart is currently empty

CWI1-2 HCL

Name: CWI1-2 HCL
Brand: TargetMol
SKU: T67930L
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T67930LCas No. 2408590-37-2

CWI1-2 HCL is an effective IGF2BP2 inhibitor, which can induce apoptosis and differentiation by binding IGF2BP2 and inhibiting its interaction with M6A-modified target transcription, and has therapeutic effects on leukemia.

CWI1-2 HCL

😃Good

Purity: 98.09%

Catalog No. T67930LCas No. 2408590-37-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$156	In Stock	In Stock
25 mg	$313	In Stock	In Stock
50 mg	$455	In Stock	In Stock
100 mg	$645	In Stock	In Stock
200 mg	$887	-	In Stock
1 mL x 10 mM (in DMSO)	$125	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.09%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CWI1-2 HCL is an effective IGF2BP2 inhibitor, which can induce apoptosis and differentiation by binding IGF2BP2 and inhibiting its interaction with M6A-modified target transcription, and has therapeutic effects on leukemia.
In vitro	CWI1-2 (0-1 μM, 24 h) hydrochloride demonstrates significant anti-leukemia efficacy.[1]
In vivo	CWI1-2 hydrochloride (5 mg/kg, i.v., once daily, 7-10 days) significantly delays leukemia onset and prolongs survival in BMT recipient B6.SJL (CD45.1) mice, without significantly affecting body weight.[1]

Chemical Properties

Molecular Weight	556.23
Formula	C₂₂H₁₈Cl₄N₆O₃
Cas No.	2408590-37-2
Smiles	OC1=CC=C(Cl)C=C1/C=N\N/C(N/N=C/C2=CC(Cl)=CC=C2O)=N/N=C/C3=CC(Cl)=CC=C3O.Cl

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 145 mg/mL (260.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (1.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7978 mL	8.9891 mL	17.9782 mL	89.8909 mL
5 mM	0.3596 mL	1.7978 mL	3.5956 mL	17.9782 mL
10 mM	0.1798 mL	0.8989 mL	1.7978 mL	8.9891 mL
20 mM	0.0899 mL	0.4495 mL	0.8989 mL	4.4945 mL
50 mM	0.0360 mL	0.1798 mL	0.3596 mL	1.7978 mL
100 mM	0.0180 mL	0.0899 mL	0.1798 mL	0.8989 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc