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ZLN005

Name: ZLN005
Brand: TargetMol
SKU: T1802
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T1802Cas No. 49671-76-3

ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α.

ZLN005

🥰Excellent

Purity: 99.86%

Catalog No. T1802Cas No. 49671-76-3

ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$51	In Stock	In Stock
25 mg	$92	In Stock	In Stock
50 mg	$175	In Stock	In Stock
100 mg	$278	In Stock	In Stock
200 mg	$417	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α.
In vitro	ZLN005 (15 mg/kg, p.o.) exhibits anti-hyperglycemic and anti-hyperlipidemic effects, and enhances insulin sensitivity in db/db mice without effecting lean mice.
In vivo	In L6 myotubes, ZLN005 enhances glucose uptake and fatty acid oxidation by activating AMP-activated protein kinase (AMPK), and it elevates the expression of PGC-1α genes and downstream genes without significant toxicity. However, the same effects are not observed in primary rat hepatocytes, indicating cell-specific actions.

Chemical Properties

Molecular Weight	250.34
Formula	C₁₇H₁₈N₂
Cas No.	49671-76-3
Smiles	CC(C)(C)c1ccc(cc1)-c1nc2ccccc2[nH]1
Relative Density.	1.102 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 2 mg/mL (7.99 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 85 mg/mL (339.54 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9946 mL	19.9728 mL	39.9457 mL	199.7284 mL
5 mM	0.7989 mL	3.9946 mL	7.9891 mL	39.9457 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.3995 mL	1.9973 mL	3.9946 mL	19.9728 mL
20 mM	0.1997 mL	0.9986 mL	1.9973 mL	9.9864 mL
50 mM	0.0799 mL	0.3995 mL	0.7989 mL	3.9946 mL
100 mM	0.0399 mL	0.1997 mL	0.3995 mL	1.9973 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc