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Thalidomide-O-amido-C3-COOH (Synonyms: E3 ligase Ligand-Linker Conjugates 15, Cereblon Ligand-Linker Conjugates...)

Name: Thalidomide-O-amido-C3-COOH
Brand: TargetMol
SKU: T17914
Rating: 4.5 (1 reviews)

Catalog No. T17914 Copy Product Info

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Thalidomide-O-amido-C3-COOH is a synthesized conjugate of an E3 ligase ligand-linker compound that combines a cereblon ligand (derived from Thalidomide) with a linker commonly employed in PROTAC technology.

Thalidomide-O-amido-C3-COOH

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Catalog No. T17914

Synonyms E3 ligase Ligand-Linker Conjugates 15, Cereblon Ligand-Linker Conjugates 7

Cas No. 2308035-51-8

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$61	5 days	5 days
5 mg	$98	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Thalidomide-O-amido-C3-COOH is a synthesized conjugate of an E3 ligase ligand-linker compound that combines a cereblon ligand (derived from Thalidomide) with a linker commonly employed in PROTAC technology.
Synonyms	E3 ligase Ligand-Linker Conjugates 15, Cereblon Ligand-Linker Conjugates 7

Chemical Properties

Molecular Weight	417.37
Formula	C₁₉H₁₉N₃O₈
Cas No.	2308035-51-8
Smiles	O=C(O)CCCNC(=O)COC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55.5 mg/mL (132.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.99 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3960 mL	11.9798 mL	23.9596 mL	119.7978 mL
5 mM	0.4792 mL	2.3960 mL	4.7919 mL	23.9596 mL
10 mM	0.2396 mL	1.1980 mL	2.3960 mL	11.9798 mL
20 mM	0.1198 mL	0.5990 mL	1.1980 mL	5.9899 mL
50 mM	0.0479 mL	0.2396 mL	0.4792 mL	2.3960 mL
100 mM	0.0240 mL	0.1198 mL	0.2396 mL	1.1980 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc