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Thalidomide-O-amido-C3-COOH

Name: Thalidomide-O-amido-C3-COOH
Brand: TargetMol
SKU: T17914
Rating: 4.5 (1 reviews)

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Catalog No. T17914Cas No. 2308035-51-8

Alias E3 ligase Ligand-Linker Conjugates 15, Cereblon Ligand-Linker Conjugates 7

Thalidomide-O-amido-C3-COOH is a synthesized conjugate of an E3 ligase ligand-linker compound that combines a cereblon ligand (derived from Thalidomide) with a linker commonly employed in PROTAC technology.

Thalidomide-O-amido-C3-COOH

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Catalog No. T17914Alias E3 ligase Ligand-Linker Conjugates 15, Cereblon Ligand-Linker Conjugates 7Cas No. 2308035-51-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$61	5 days	5 days
5 mg	$98	Backorder	Backorder

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Thalidomide-O-amido-C3-COOH is a synthesized conjugate of an E3 ligase ligand-linker compound that combines a cereblon ligand (derived from Thalidomide) with a linker commonly employed in PROTAC technology.
Synonyms	E3 ligase Ligand-Linker Conjugates 15, Cereblon Ligand-Linker Conjugates 7

Chemical Properties

Molecular Weight	417.37
Formula	C₁₉H₁₉N₃O₈
Cas No.	2308035-51-8
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55.5 mg/mL (132.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3960 mL	11.9798 mL	23.9596 mL	119.7978 mL
5 mM	0.4792 mL	2.3960 mL	4.7919 mL	23.9596 mL
10 mM	0.2396 mL	1.1980 mL	2.3960 mL	11.9798 mL
20 mM	0.1198 mL	0.5990 mL	1.1980 mL	5.9899 mL
50 mM	0.0479 mL	0.2396 mL	0.4792 mL	2.3960 mL
100 mM	0.0240 mL	0.1198 mL	0.2396 mL	1.1980 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc