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NJK14047

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Catalog No. T87014Cas No. 1800576-41-3

NJK14047 inhibits p38 MAPK and prevents the differentiation of naive T-cells into Th1 and Th17 cells, thereby ameliorating collagen-induced rheumatoid arthritis and Imiquimod-induced psoriasis in mice [1].

NJK14047

NJK14047

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Catalog No. T87014Cas No. 1800576-41-3
NJK14047 inhibits p38 MAPK and prevents the differentiation of naive T-cells into Th1 and Th17 cells, thereby ameliorating collagen-induced rheumatoid arthritis and Imiquimod-induced psoriasis in mice [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
NJK14047 inhibits p38 MAPK and prevents the differentiation of naive T-cells into Th1 and Th17 cells, thereby ameliorating collagen-induced rheumatoid arthritis and Imiquimod-induced psoriasis in mice [1].
In vitro
NJK14047 (3-10 μM) suppresses the expression of inflammatory cytokines IL-1β, TNF-α, IL-6, IL-17A, RANKL, and MMP-3 in SW982 synovial cells stimulated by lipopolysaccharide [1]. NJK14047 (3-10 μM) also inhibits the differentiation of naive CD4+ T cells into Th1, Th2, and Th17 cells in a dose-dependent manner [1].
In vivo
In the collagen-induced arthritis (CIA) model in DBA-1J mice and the imiquimod-induced psoriasis (IIP) model in BALB/c mice, the compound NJK14047 (2.5 mg/kg, intraperitoneal injection, administered over 7 days for IIP in BALB/c mice and 21 days for CIA in DBA-1J mice) significantly ameliorated the pathological symptoms of rheumatoid arthritis and psoriasis. This chemical effectively inhibited the expression of Th1, Th2, Th17, and Treg cell cytokines, mitigating arthritis, cartilage damage, inflammation, synovial hyperplasia, bone erosion, and tumor formation caused by CIA. It also improved the hyperproliferation of keratinocytes associated with imiquimod-induced psoriasis. [1]
Chemical Properties
Molecular Weight445.51
FormulaC27H27NO5
Cas No.1800576-41-3
SmilesCC=1C(=CC(C(NC2CC2)=O)=CC1)C3=CC=C(C(=O)C4=CC=C(OCC(CO)O)C=C4)C=C3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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