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SSK1

Name: SSK1
Brand: TargetMol
SKU: T37450
Price: 156 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T37450Cas No. 2629250-69-5

SSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, and promote mitochondrial DNA damage in senescent cells.

SSK1

🥰Excellent

Purity: 99.48%

Catalog No. T37450Cas No. 2629250-69-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$156	In Stock	In Stock
5 mg	$372	In Stock	In Stock
10 mg	$562	In Stock	In Stock
25 mg	$893	In Stock	In Stock
50 mg	$1,230	In Stock	In Stock
100 mg	$1,730	-	In Stock
200 mg	$2,330	-	In Stock
1 mL x 10 mM (in DMSO)	$488	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.48%

ee:100%

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COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description	SSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, and promote mitochondrial DNA damage in senescent cells.
In vitro	SSK1 (0.5 μM; 12-72 h) is activated by lysosomal β-galactosidase, selectively kills senescent cells by activating p38 MAPK, and inducing apoptosis[1].
In vivo	Lung-injured mice (3-6 months old) received intratracheal administration of bleomycin (1.5 mg/kg) and were subjected to intraperitoneal injection of SSK1 (0.5 mg/kg) or vehicle (DMSO) for two consecutive days each week for 4 weeks. The results indicate that SSK1 can eliminate SA-β-gal-positive senescent cells and reduce aging-related markers in vivo[1].

Chemical Properties

Molecular Weight	788.61
Formula	C₃₁H₃₄F₂N₄O₁₈
Cas No.	2629250-69-5
Smiles	[H][C@]1(O[C@H](CO)[C@@H](O)C1(F)F)n1ccc(NC(=O)OCc2ccc(O[C@@H]3O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)c(c2)[N+]([O-])=O)nc1=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (190.20 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (6.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2681 mL	6.3403 mL	12.6805 mL	63.4027 mL
5 mM	0.2536 mL	1.2681 mL	2.5361 mL	12.6805 mL
10 mM	0.1268 mL	0.6340 mL	1.2681 mL	6.3403 mL
20 mM	0.0634 mL	0.3170 mL	0.6340 mL	3.1701 mL
50 mM	0.0254 mL	0.1268 mL	0.2536 mL	1.2681 mL
100 mM	0.0127 mL	0.0634 mL	0.1268 mL	0.6340 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc