Beta Klotho Protein, Human, Recombinant (His)

Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.

Pack Size	Availability	Price/USD
100 μg	5 days	$ 1,620.00
500 μg	5 days	$ 6,520.00
1 mg	5 days	$ 10,870.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 1,620.00

500 μg

5 days

$ 6,520.00

1 mg

5 days

$ 10,870.00

Description

Species	Human
Expression System	HEK293
Tag	C-His
Accession Number	Q86Z14
Synonyms	beta-klotho, MGC142213, betaKlotho, BKL, β-klotho, KLB, klotho beta like, Klotho β, βKlotho, β Klotho, klotho β like, Klotho beta
Construction	Recombinant Human Beta Klotho Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Met30-Thr983.[Accession \|Q86Z14]
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Molecular Weight	The protein has a predicted MW of 111.6 kDa. Due to glycosylation, the protein migrates to 115-130 kDa based on Tris-Bis PAGE result.

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability & Storage	-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.