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Anti-Phospho-MEK1/2 (Ser218, Ser222) Antibody (7E636)
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Catalog No. TMAB-01451
Anti-Phospho-MEK1/2 (Ser218, Ser222) Antibody (7E636) is a Rabbit antibody targeting Phospho-MEK1/2 (Ser218, Ser222). Anti-Phospho-MEK1/2 (Ser218, Ser222) Antibody (7E636) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Anti-Phospho-MEK1/2 (Ser218, Ser222) Antibody (7E636)
Anti-Phospho-MEK1/2 (Ser218, Ser222) Antibody (7E636)
😃Good
Catalog No. TMAB-01451
Anti-Phospho-MEK1/2 (Ser218, Ser222) Antibody (7E636) is a Rabbit antibody targeting Phospho-MEK1/2 (Ser218, Ser222). Anti-Phospho-MEK1/2 (Ser218, Ser222) Antibody (7E636) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 μL | $154 | 7-10 days | |
| 50 μL | $271 | 7-10 days | |
| 100 μL | $488 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: WB,IHC-P,IHC-Fr,ICC/IF,IF Reactivity: Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Rabbit) |
| Ig Type | IgG |
| Clone | 7E636 |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Rabbit) |
| Verified Activity | Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Rat Cerebrum tissue lysates Lane 3: Human Du145 cell lysates Lane 4: Human HepG2 cell lysates Lane 5: Human U251 cell lysates Lane 6: Human A549 cell cell lysates Primary: Anti-Phospho-MEK1/2 (Ser218 + Ser222) (TMAB-01451) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 45 kDa Observed band size: 45 kDa |
| Application | WB,IHC-P,IHC-Fr,ICC/IF,IF |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:50-200; ICC/IF: 1:50-200; IF: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole body. Cytoplasm. Nucleus. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human MEK1 around the phosphorylation site of Ser218/222 |
| Antigen Species | Human |
| Gene ID | 5605 |
| Uniprot ID | |
| Biology Area | MAPK pathway,MAPK Pathway,Tyrosine Kinases |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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