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Rosamultin

Name: Rosamultin
Brand: TargetMol
SKU: T5783
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5783Cas No. 88515-58-6

Rosamultin has antioxidant, antiinflammatory/antinociceptive properties,and has anti-human immunodeficiency virus (HIV) activity.

Rosamultin

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Purity: 99.51%

Catalog No. T5783Cas No. 88515-58-6

Rosamultin has antioxidant, antiinflammatory/antinociceptive properties,and has anti-human immunodeficiency virus (HIV) activity.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$34	In Stock	In Stock
5 mg	$60	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$158	In Stock	In Stock
50 mg	$232	In Stock	In Stock
100 mg	$343	-	In Stock
1 mL x 10 mM (in DMSO)	$92	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.51%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Rosamultin has antioxidant, antiinflammatory/antinociceptive properties,and has anti-human immunodeficiency virus (HIV) activity.
In vitro	Rosamultin isolated from the root of R. rugosa inhibited HIV-1 protease by 53% at a concentration of 100 microM.
Kinase Assay	A substrate, His-Lys-Ala-ArgVal-Leu-(pNO2-Phe)-Glu-Ala-Nle-Ser-NH2, Inc. For the HIV1 protease assay, the stock solution of the prepared enzyme was diluted. The extracts or compounds(Rosamultin) tested were dissolved in dimethyl sulfoxide (10% in the reaction mixture). A reaction mixture (5 uL) composed of 1 L of 50 uM sodium acetate (pH 5.0), 1 uL of a substrate solution, 1uL of the plant extract or compound solution, and 2 uL of HIV1 protease solution, was stirred, centrifuged, and then incubated at 37℃ for 1 hour in a microtube. A control reaction was performed under the same conditions without plant extract or compounds. The reaction was stopped by heating at 90 ℃ for 1 minute. Thirty-five microliters of autoclaved water was added into the reaction mixture, and an aliquot of 5 uL was analyzed by high-performance liquid chromatography (HPLC).

Chemical Properties

Molecular Weight	650.84
Formula	C₃₆H₅₈O₁₀
Cas No.	88515-58-6
Smiles	[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@](C)(O)[C@H](C)CC[C@@]5(CC[C@@]34C)C(=O)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@]1(C)C[C@@H](O)[C@H](O)C2(C)C
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (230.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5365 mL	7.6824 mL	15.3648 mL	76.8238 mL
5 mM	0.3073 mL	1.5365 mL	3.0730 mL	15.3648 mL
10 mM	0.1536 mL	0.7682 mL	1.5365 mL	7.6824 mL
20 mM	0.0768 mL	0.3841 mL	0.7682 mL	3.8412 mL
50 mM	0.0307 mL	0.1536 mL	0.3073 mL	1.5365 mL
100 mM	0.0154 mL	0.0768 mL	0.1536 mL	0.7682 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc