Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

P2Y14R antagonist 1

🥰Excellent
Catalog No. T88677Cas No. 2728291-29-8

P2Y14R antagonist 1 (compound I-17) is a selective and potent P2Y14R antagonist (IC50=0.6 nM) with oral activity and good bioavailability that inhibits monosodium urate-induced inflammatory response in acute gouty arthritis by reducing inflammatory factor release via the NLRP3/GSDMD signaling pathway and cellular pyroptosis.

P2Y14R antagonist 1

P2Y14R antagonist 1

🥰Excellent
Purity: 98.88%
Catalog No. T88677Cas No. 2728291-29-8
P2Y14R antagonist 1 (compound I-17) is a selective and potent P2Y14R antagonist (IC50=0.6 nM) with oral activity and good bioavailability that inhibits monosodium urate-induced inflammatory response in acute gouty arthritis by reducing inflammatory factor release via the NLRP3/GSDMD signaling pathway and cellular pyroptosis.
Pack SizePriceAvailabilityQuantity
1 mg$42In Stock
5 mg$98In Stock
10 mg$156In Stock
25 mg$313In Stock
50 mg$493In Stock
100 mg$786In Stock
Add to Cart
Add to Quotation
Bulk & Custom
Questions
View More
Select Batch
Purity:98.88%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
P2Y14R antagonist 1 (compound I-17) is a selective and potent P2Y14R antagonist (IC50=0.6 nM) with oral activity and good bioavailability that inhibits monosodium urate-induced inflammatory response in acute gouty arthritis by reducing inflammatory factor release via the NLRP3/GSDMD signaling pathway and cellular pyroptosis.
Targets&IC50
P2Y14R (HEK293 cells):0.11 nM (Kᴅ), P2Y14R (HEK293 cells):0.60 nM
In vitro
P2Y14R antagonist 1 (Compound I-17)showed potent inhibition of P2Y14R in HEK293 cells (IC₅₀ = 0.60 nM; K_D = 0.11 nM) and had no significant effect on other P2Y receptors[1].
In RAW264.7 cells, P2Y14R antagonist 1 (10–40 μM) inhibited MSU+LPS-induced IL-1β, IL-6, and IL-18 release, reduced NLRP3 and GSDMD expression, and suppressed pyroptosis[1].
In vivo
P2Y14R antagonist 1(compound I-17)exhibited good oral bioavailability (F = 75%) in rats (20 mg/kg, p.o., T₁/₂ = 12.6 h). In an MSU-induced mouse model of acute gouty arthritis, P2Y14R antagonist 1 effectively reduced paw swelling, downregulated pro-inflammatory cytokines (IL-1β, IL-6, IL-18), attenuated immune cell infiltration and joint histopathological damage, and decreased NLRP3 expression[1].
Chemical Properties
Molecular Weight346.18
FormulaC15H12BrN3O2
Cas No.2728291-29-8
SmilesO=C(NC=1C=CC=2N=CNC2C1)COC3=CC=C(Br)C=C3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (115.55 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8887 mL14.4434 mL28.8867 mL144.4335 mL
5 mM0.5777 mL2.8887 mL5.7773 mL28.8867 mL
10 mM0.2889 mL1.4443 mL2.8887 mL14.4434 mL
20 mM0.1444 mL0.7222 mL1.4443 mL7.2217 mL
50 mM0.0578 mL0.2889 mL0.5777 mL2.8887 mL
100 mM0.0289 mL0.1444 mL0.2889 mL1.4443 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy P2Y14R antagonist 1 | purchase P2Y14R antagonist 1 | P2Y14R antagonist 1 cost | order P2Y14R antagonist 1 | P2Y14R antagonist 1 chemical structure | P2Y14R antagonist 1 in vivo | P2Y14R antagonist 1 in vitro | P2Y14R antagonist 1 formula | P2Y14R antagonist 1 molecular weight