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DC-S239

Name: DC-S239
Brand: TargetMol
SKU: T60002
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60002Cas No. 303141-21-1

DC-S239 (DC-S239) is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.

DC-S239

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Purity: 99.37%

Catalog No. T60002Cas No. 303141-21-1

DC-S239 (DC-S239) is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$38	-	In Stock
5 mg	$64	-	In Stock
10 mg	$103	-	In Stock
25 mg	$208	-	In Stock
50 mg	$337	-	In Stock
100 mg	$535	-	In Stock
200 mg	$732	-	In Stock
1 mL x 10 mM (in DMSO)	$70	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.37%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	DC-S239 (DC-S239) is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.
In vitro	DC-S239 (0-100 μM) inhibits the proliferation of MCF7, HL60 and MV4-11 cells in a dose-dependent manner with the IC50 values of 10.93 μM and 16.43 μM, respectively. DC-S239 inhibits DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a by less than 45%, whereas it inhibits SET7 by 90% at concentrations of 100 μM[1].

Chemical Properties

Molecular Weight	349.36
Formula	C₁₅H₁₅N₃O₅S
Cas No.	303141-21-1
Smiles	CCOC(=O)c1c(N)sc(C(=O)Nc2cccc(c2)[N+]([O-])=O)c1C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.5 mg/mL (15.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8624 mL	14.3119 mL	28.6238 mL	143.1188 mL
5 mM	0.5725 mL	2.8624 mL	5.7248 mL	28.6238 mL
10 mM	0.2862 mL	1.4312 mL	2.8624 mL	14.3119 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc