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DC-S239

Name: DC-S239
Brand: TargetMol
SKU: T60002
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60002Cas No. 303141-21-1

DC-S239 (DC-S239) is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.

DC-S239

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Purity: 99.37%

Catalog No. T60002Cas No. 303141-21-1

DC-S239 (DC-S239) is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.

Pack Size	Price	Availability
1 mg	$45	In Stock
5 mg	$106	In Stock
10 mg	$172	In Stock
25 mg	$347	In Stock
50 mg	$562	In Stock
100 mg	$892	In Stock
200 mg	$1,220	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock

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Purity:99.37%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	DC-S239 (DC-S239) is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.
In vitro	DC-S239 (0-100 μM) inhibits the proliferation of MCF7, HL60 and MV4-11 cells in a dose-dependent manner with the IC50 values of 10.93 μM and 16.43 μM, respectively. DC-S239 inhibits DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a by less than 45%, whereas it inhibits SET7 by 90% at concentrations of 100 μM[1].

Chemical Properties

Molecular Weight	349.36
Formula	C₁₅H₁₅N₃O₅S
Cas No.	303141-21-1
Smiles	CCOC(=O)c1c(N)sc(C(=O)Nc2cccc(c2)[N+]([O-])=O)c1C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.5 mg/mL (15.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8624 mL	14.3119 mL	28.6238 mL	143.1188 mL
5 mM	0.5725 mL	2.8624 mL	5.7248 mL	28.6238 mL
10 mM	0.2862 mL	1.4312 mL	2.8624 mL	14.3119 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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