Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

AR/BRD4 RIPTAC-1

Name: AR/BRD4 RIPTAC-1
Brand: TargetMol
SKU: T211016
Rating: 4.5 (1 reviews)

(Synonyms: Antiproliferative agent-71) Copy Product Info

🥰Excellent

Synonyms: Antiproliferative agent-71

Catalog No. T211016 Copy Product Info

🥰Excellent

AR/BRD4 RIPTAC-1 (Compound II-5) is an orally active Regulatory-inducible proximity-targeting chimera (RIPTAC). AR/BRD4 RIPTAC-1 induces the formation of a stable ternary complex between the androgen receptor (AR) and BRD4, thereby blocking BRD4 function. AR/BRD4 RIPTAC-1 inhibits the growth and proliferation of tumor cells. AR/BRD4 RIPTAC-1 holds promise for use in prostate cancer research. AR/BRD4 RIPTAC-1 is additionally applicable in molecular oncology research for investigating androgen receptor–epigenetic regulator interactions and for studying proximity-induced protein complex formation mechanisms in tumor-associated transcriptional regulation systems.

Cas No. 3083307-42-7

Pack Size	Price	USA Stock	Global Stock
1 mg	$564	7-10 days	7-10 days
5 mg	$1,130	7-10 days	7-10 days
10 mg	$1,580	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$2,250	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

Product Introduction

Bioactivity

Description	AR/BRD4 RIPTAC-1 (Compound II-5) is an orally active Regulatory-inducible proximity-targeting chimera (RIPTAC). AR/BRD4 RIPTAC-1 induces the formation of a stable ternary complex between the androgen receptor (AR) and BRD4, thereby blocking BRD4 function. AR/BRD4 RIPTAC-1 inhibits the growth and proliferation of tumor cells. AR/BRD4 RIPTAC-1 holds promise for use in prostate cancer research. AR/BRD4 RIPTAC-1 is additionally applicable in molecular oncology research for investigating androgen receptor–epigenetic regulator interactions and for studying proximity-induced protein complex formation mechanisms in tumor-associated transcriptional regulation systems.
Targets & IC50	T47D cells:＜0.5 μM (GI50)
In vitro	Methods：T47D cells were cultured in vitro and treated with AR/BRD4 RIPTAC-1 (Antiproliferative agent-71) for 72 hours, then the half-maximal growth inhibitory concentration GI₅₀ was determined. Results：AR/BRD4 RIPTAC-1 (Antiproliferative agent-71) inhibited the growth of T47D cells with a GI₅₀ lower than 0.5 μM [1].
In vivo	Methods：CB17.SCID mice bearing VCaP tumors were orally administrated for 7 consecutive days, and tumor growth was monitored. Results：AR/BRD4 RIPTAC-1 (Antiproliferative agent-71) effectively inhibited tumor proliferation in vivo [1].
Synonyms	Antiproliferative agent-71

Chemical Properties

Molecular Weight	907.09
Formula	C₅₀H₅₄N₁₀O₅S
Cas No.	3083307-42-7
Smiles	O(C1CC2(C1)CCN(CC2)C=3N=CC(C(N[C@H]4C(C)(C)[C@H](OC5=CC(OC)=C(C#N)C=C5)C4(C)C)=O)=CN3)C6=CC=C(C=C6)C=7C8=C(N9C([C@H](CC%10=NC=CO%10)N7)=NN=C9C)SC(C)=C8C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (44.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1024 mL	5.5121 mL	11.0243 mL	55.1213 mL
5 mM	0.2205 mL	1.1024 mL	2.2049 mL	11.0243 mL
10 mM	0.1102 mL	0.5512 mL	1.1024 mL	5.5121 mL
20 mM	0.0551 mL	0.2756 mL	0.5512 mL	2.7561 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: AR/BRD4 RIPTAC-1 chemical structure | AR/BRD4 RIPTAC-1 in vivo | AR/BRD4 RIPTAC-1 in vitro | AR/BRD4 RIPTAC-1 formula | AR/BRD4 RIPTAC-1 molecular weight