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Endothelin-1 (1-15), amide, human

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Catalog No. TP2246

Endothelin-1 is one of the there isoforms of endothelin (identified as ET-1, -2, -3) with varying regions of expression and binding to at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC.

Endothelin-1 (1-15), amide, human

Endothelin-1 (1-15), amide, human

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Catalog No. TP2246
Endothelin-1 is one of the there isoforms of endothelin (identified as ET-1, -2, -3) with varying regions of expression and binding to at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC.
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1 mg$543InquiryInquiry
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Endothelin-1 is one of the there isoforms of endothelin (identified as ET-1, -2, -3) with varying regions of expression and binding to at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC.
In vitro
Endothelins are the most potent vasoconstrictors known. In a healthy individual, a delicate balance between vasoconstriction and vasodilation is maintained by endothelin and other vasoconstrictors as well as nitric oxide, prostacyclin, and other vasodilators. The ubiquitous distribution of endothelin peptides and receptors implicates its involvement in a wide variety of physiological and pathological processes in the body. Among numerous diseases potentially occurring from endothelin dysregulation are several types of cancer, cerebral vasospasm following subarachnoid hemorrhage, arterial hypertension, and other cardiovascular disorder, pain mediation, type II diabetes, etc [2][3].
Chemical Properties
Molecular Weight1717.04
FormulaC70H109N17O23S5
SmilesO=C4N[C@@]([H])(CO)C(=O)N[C@]1([H])C[S][S]C[C@@]([H])(NC(=O)[C@]([H])(NC(=O)[C@]([H])(NC(=O)[C@]([H])(NC(=O)[C@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@]([H])(NC1=O)CO)CO)CC(C)(C)[H])CC[S]C)CC(=O)O)CCCCN)CCC(O)=O)C(=O)N[C@@]([H])(C(=O)N[C@@]([H])(C/C2=C/C=C(/O)C=C2)C(=O)N[C@]([H])(C/C3=C/C=CC=C3)C(=O)N[C@]([H])(C[S][S]C[C@@]4(N)[H])C(=O)N[C@]([H])(CC=5N=CNC=5)C(=O)N[C@]([H])(CC(C)(C)[H])C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@]([H])(C(=O)N[C@@]([H])(C(=O)N[C@]([H])(C/C6=C/NC=7C=CC=CC6=7)C(O)=O)[C@](C)([H])CC)[C@](C)([H])CC)C(C)(C)[H]
Relative Density.no data available
SequenceH-Cys(1)-Ser-D-Cys(2)-D-Ser-Ser-Leu-D-Met-D-Asp-D-Lys-D-Glu-D-Cys(2)-D-Val-Tyr-D-Phe-D-Cys(1)-D-His-D-Leu-Asp-Ile-D-aIle-D-Trp-OH
Sequence ShortCSCSSLMDKECVYFCHLDIXW
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: Soluble
1% acetic acid: Soluble

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Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

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Keywords

Endothelin-1 , amide, humanEndothelin1 (115), amide, humanEndothelin 1 (1 15), amide, human
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