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Roflupram

Name: Roflupram
Brand: TargetMol
SKU: T24061
Rating: 4.5 (1 reviews)

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Catalog No. T24061Cas No. 1093412-18-0

Alias FFPM

Roflupram is a selective PDE4 inhibitor (IC50=26.2 nM) with oral bioavailability and blood-brain barrier permeability, capable of reversing cognitive deficits and suppressing pro-inflammatory factor production.

Roflupram

🥰Excellent

Catalog No. T24061Alias FFPMCas No. 1093412-18-0

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Product Introduction

Bioactivity

Description	Roflupram is a selective PDE4 inhibitor (IC50=26.2 nM) with oral bioavailability and blood-brain barrier permeability, capable of reversing cognitive deficits and suppressing pro-inflammatory factor production.
Targets&IC50	PDE4:26.2 nM
Synonyms	FFPM

Chemical Properties

Molecular Weight	314.32
Formula	C₁₆H₂₀F₂O₄
Cas No.	1093412-18-0
Smiles	O=C(C1=CC=C(OC(F)F)C(OC2COCC2)=C1)CC(C)C
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (254.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1815 mL	15.9074 mL	31.8147 mL	159.0736 mL
5 mM	0.6363 mL	3.1815 mL	6.3629 mL	31.8147 mL
10 mM	0.3181 mL	1.5907 mL	3.1815 mL	15.9074 mL
20 mM	0.1591 mL	0.7954 mL	1.5907 mL	7.9537 mL
50 mM	0.0636 mL	0.3181 mL	0.6363 mL	3.1815 mL
100 mM	0.0318 mL	0.1591 mL	0.3181 mL	1.5907 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc