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Anticancer agent 193
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Catalog No. T209422
Anticanceragent 193 (compound D3-3) is an inducer of ferritinophagy, ultimately triggering ferroptosis. This compound stimulates the production of lipid ROS and significantly enhances the release of ferrous ions in colorectal cancer cells through an autophagy-dependent mechanism.
Anticancer agent 193
Anticancer agent 193
😃Good
Catalog No. T209422
Anticanceragent 193 (compound D3-3) is an inducer of ferritinophagy, ultimately triggering ferroptosis. This compound stimulates the production of lipid ROS and significantly enhances the release of ferrous ions in colorectal cancer cells through an autophagy-dependent mechanism.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Anticanceragent 193 (compound D3-3) is an inducer of ferritinophagy, ultimately triggering ferroptosis. This compound stimulates the production of lipid ROS and significantly enhances the release of ferrous ions in colorectal cancer cells through an autophagy-dependent mechanism. |
| In vitro | Anticancer agent 193 (D3-3; 2.5-30 μM; 12-48 h) inhibits HCT-116 cell proliferation with IC50 values of 15.06 μM, 11.18 μM, and 5.87 μM at 12, 24, and 48 hours, respectively. At concentrations of 5-20 μM over 12 hours, it significantly increases the ratio of autophagy marker proteins LC3B-II/LC3B-I and enhances the expression of ferritin subunit FTH1. Additionally, Anticancer agent 193 (D3-3) promotes the accumulation of lipid ROS and markedly increases divalent iron levels in a concentration-dependent manner in HCT-116 cells. |
| In vivo | Agent 193 (D3-3; 30-60 mg/kg; intraperitoneal injection; daily; for 2 weeks) inhibits tumor growth and enhances lipid peroxidation in the HCT-116 xenograft model. |
| Formula | C34H47ClN2O6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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