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Anticancer agent 193
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Catalog No. T209422
Anticanceragent 193 (compound D3-3) is an inducer of ferritinophagy, ultimately triggering ferroptosis. This compound stimulates the production of lipid ROS and significantly enhances the release of ferrous ions in colorectal cancer cells through an autophagy-dependent mechanism.
Anticancer agent 193
Anticancer agent 193
😃Good
Catalog No. T209422
Anticanceragent 193 (compound D3-3) is an inducer of ferritinophagy, ultimately triggering ferroptosis. This compound stimulates the production of lipid ROS and significantly enhances the release of ferrous ions in colorectal cancer cells through an autophagy-dependent mechanism.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Backorder | Backorder | |
| 50 mg | Inquiry | Backorder | Backorder |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Anticanceragent 193 (compound D3-3) is an inducer of ferritinophagy, ultimately triggering ferroptosis. This compound stimulates the production of lipid ROS and significantly enhances the release of ferrous ions in colorectal cancer cells through an autophagy-dependent mechanism. |
| In vitro | Anticancer agent 193 (D3-3; 2.5-30 μM; 12-48 h) inhibits HCT-116 cell proliferation with IC50 values of 15.06 μM, 11.18 μM, and 5.87 μM at 12, 24, and 48 hours, respectively. At concentrations of 5-20 μM over 12 hours, it significantly increases the ratio of autophagy marker proteins LC3B-II/LC3B-I and enhances the expression of ferritin subunit FTH1. Additionally, Anticancer agent 193 (D3-3) promotes the accumulation of lipid ROS and markedly increases divalent iron levels in a concentration-dependent manner in HCT-116 cells. |
| In vivo | Agent 193 (D3-3; 30-60 mg/kg; intraperitoneal injection; daily; for 2 weeks) inhibits tumor growth and enhances lipid peroxidation in the HCT-116 xenograft model. |
| Formula | C34H47ClN2O6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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