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NOD2 antagonist 1

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Catalog No. T63088Cas No. 2411441-54-6

NOD2 antagonist 1 (compound 32) is an effective and selective NOD2 antagonist (IC50: 5.23 μM). In THP-1 cells, it represses Muramyl DiDP (MDP)-induced IL-8 secretion and, in PBMCs cells, inhibits MDP-induced elevation of IL-6, IL-10, and TNF-α.

NOD2 antagonist 1

NOD2 antagonist 1

😃Good
Catalog No. T63088Cas No. 2411441-54-6
NOD2 antagonist 1 (compound 32) is an effective and selective NOD2 antagonist (IC50: 5.23 μM). In THP-1 cells, it represses Muramyl DiDP (MDP)-induced IL-8 secretion and, in PBMCs cells, inhibits MDP-induced elevation of IL-6, IL-10, and TNF-α.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,380-In Stock
50 mg$1,798-In Stock
100 mg$2,885-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
NOD2 antagonist 1 (compound 32) is an effective and selective NOD2 antagonist (IC50: 5.23 μM). In THP-1 cells, it represses Muramyl DiDP (MDP)-induced IL-8 secretion and, in PBMCs cells, inhibits MDP-induced elevation of IL-6, IL-10, and TNF-α.
Targets&IC50
NOD2:5.23 μM
Chemical Properties
Molecular Weight474.57
FormulaC26H26N4O3S
Cas No.2411441-54-6
SmilesC(C(NC=1C=C2C(=CC1)CCC2)=O)N3C=4C(N=C3CCNS(=O)(=O)C5=CC=CC=C5)=CC=CC4
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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