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BI 01383298
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Catalog No. T5324Cas No. 2227549-00-8
BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
BI 01383298
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Purity: 99.71%
Catalog No. T5324Cas No. 2227549-00-8
BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $46 | In Stock | In Stock | |
| 25 mg | $100 | In Stock | In Stock | |
| 50 mg | $163 | In Stock | In Stock | |
| 100 mg | $260 | In Stock | In Stock | |
| 200 mg | $370 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.71%
Appearance:Solid
Color:White
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Product Introduction
BI 01383298 AI Summary
BI 01383298 demonstrates cell-type-specific bioactivities impacting cell viability and protein thermal stability. In terms of cell viability, the compound shows varying effects: in HEK293T cells, growth rates range from negative (-0.42) to positive (up to 0.95); in U2OS cells, growth rates are consistently positive, ranging from 0.72 to 0.98; and in human fibroblasts, the growth rates vary between 0.3 and 0.84. This suggests that the compound can either inhibit or promote cell growth depending on the cell type.
In protein thermal stability assays, BI 01383298 exhibits domain-specific effects with some domains showing increased stability (positive Delta TM values) and others decreased stability (negative Delta TM values). Specific domains such as M1-K294 and E122-S403 display increased stability, while domains like M1-L298 and M26-R383 exhibit decreased stability, indicating variable interaction kinetics across different protein regions.
Additionally, BI 01383298 shows significant bioactivity in affinity-based cellular interactions, particularly targeting the citrate uptake inhibition assay in HepG2 cells expressing endogenous SLC13A5, with an IC50 value of 24.0 nM. Another report shows an IC50 value of 56.0 nM for the same assay. The compound also interacts with OPRK1, exhibiting 19.0% of control in the SafetyScreen44™ assay, indicating selective modulatory effects on this target..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5). |
| Molecular Weight | 445.34 |
| Formula | C19H19Cl2FN2O3S |
| Cas No. | 2227549-00-8 |
| Smiles | Fc1ccc(CNC(=O)C2CCN(CC2)S(=O)(=O)c2cc(Cl)cc(Cl)c2)cc1 |
| Relative Density. | 1.419 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 22 mg/mL (49.4 mM), Sonication is recommended. H2O: Insoluble | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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