GBA Protein, Human, Recombinant

Name: GBA Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPH-01624
Rating: 4.5 (1 reviews)

(Synonyms: Lysosomal glycosylceramidase, Lysosomal galactosylceramidase, Lysosomal cholesterol glycosyltransferase, Lysosomal acid glucosylceramidase, Lysosomal acid GCase, Imiglucerase, Glucosylceramidase beta 1, GLUC, GC, GBA1, GBA, D-glucosyl-N-acylsphingosine glucohydrolase, Cholesteryl-beta-glucosidase, Cholesterol glucosyltransferase (SGTase), Beta-glucosylceramidase 1, Beta-glucocerebrosidase (Beta-GC), Alglucerase, Acid beta-glucosidase) Copy Product Info

Synonyms: Lysosomal glycosylceramidase, Lysosomal galactosylceramidase, Lysosomal cholesterol glycosyltransferase, Lysosomal acid glucosylceramidase, Lysosomal acid GCase, Imiglucerase, Glucosylceramidase beta 1, GLUC, GC, GBA1, GBA, D-glucosyl-N-acylsphingosine glucohydrolase, Cholesteryl-beta-glucosidase, Cholesterol glucosyltransferase (SGTase), Beta-glucosylceramidase 1, Beta-glucocerebrosidase (Beta-GC), Alglucerase, Acid beta-glucosidase

Catalog No. TMPH-01624 Copy Product Info

Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol.

Pack Size	Price	USA Stock	Global Stock
5 μg	$132	20 days	20 days
10 μg	$217	20 days	20 days
20 μg	$362	20 days	20 days
50 μg	$479	20 days	20 days
100 μg	$598	20 days	20 days
200 μg	$856	20 days	20 days
500 μg	$1,370	20 days	20 days
1 mg	$1,980	20 days	20 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol.
Species	Human
Expression System	E. coli
Tag	Tag Free
Accession Number	P04062
Amino Acid	ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITSLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
Construction	40-536 aa
Protein Purity	> 85% as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Tris-based buffer, 50% glycerol
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Synonyms	Lysosomal glycosylceramidase, Lysosomal galactosylceramidase, Lysosomal cholesterol glycosyltransferase, Lysosomal acid glucosylceramidase, Lysosomal acid GCase, Imiglucerase, Glucosylceramidase beta 1, GLUC, GC, GBA1, GBA, D-glucosyl-N-acylsphingosine glucohydrolase, Cholesteryl-beta-glucosidase, Cholesterol glucosyltransferase (SGTase), Beta-glucosylceramidase 1, Beta-glucocerebrosidase (Beta-GC), Alglucerase, Acid beta-glucosidase
Research Background

Chemical Properties

Molecular Weight

55.6 kDa (predicted)

Storage & Solubility Information

Storage

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

β-glucosylceramidase 1β-glucocerebrosidase (β-GC)β-GCβGCSGTaseGlucosylceramidase β 1Glucosylceramidase b 1GBA 1Cholesteryl-β-glucosidaseCholesteryl-b-glucosidaseb-glucosylceramidase 1b-glucocerebrosidase (b-GC)b-GCbGCBeta-GCBetaGCAcid β-glucosidaseAcid b-glucosidase

Related Tags: GBA Protein, Human, Recombinant chemical structure | GBA Protein, Human, Recombinant molecular weight