Shopping Cart

Your shopping cart is currently empty

Dihydrocyclosporin A

Name: Dihydrocyclosporin A
Brand: TargetMol
SKU: T31467
Price: 129 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T31467Cas No. 59865-15-5

Alias Dihydrocyclosporin-A

Dihydrocyclosporin A (Dihydrocyclosporin-A) is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.

Dihydrocyclosporin A

😃Good

Purity: 99.96%

Catalog No. T31467Alias Dihydrocyclosporin-ACas No. 59865-15-5

Dihydrocyclosporin A (Dihydrocyclosporin-A) is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$129	In Stock	In Stock
5 mg	$320	In Stock	In Stock
10 mg	$470	In Stock	In Stock
25 mg	$772	In Stock	In Stock
50 mg	$1,080	-	In Stock
100 mg	$1,460	-	In Stock
1 mL x 10 mM (in DMSO)	$784	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.96%

Appearance:Solid

Color:White

Resource Download

COA MS HPLC HNMR

Product Introduction

Bioactivity

Description	Dihydrocyclosporin A (Dihydrocyclosporin-A) is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.
Targets&IC50	Promastigotes:12.14(48 h,L. donovani), Promastigotes:21.24 μM(24 h,L. donovani), Intracellular amastigotes:4.84 μM(48 h,L. donovani), Intracellular amastigotes:5.23 μM(24 h,L. donovani)
In vitro	Dihydrocyclosporin A was able to inhibit the proliferation of L. donovani promastigotes (IC50: 21.24 μM and 12.14 μM at 24 h and 48 h, respectively) and intracellular amastigotes (IC50: 5.23 μM and 4.84 μM at 24 and 48 h, respectively) in vitro. Dihydrocyclosporin A caused several alterations in the morphology and ultrastructure of L. donovani, especially in the mitochondria. However, Dihydrocyclosporin A showed high cytotoxicity towards cells of the mouse macrophage cell line RAW264.7, with CC50 values of 7.98 μM (24 h) and 6.65 μM (48 h).[2].
Synonyms	Dihydrocyclosporin-A

Chemical Properties

Molecular Weight	1204.63
Formula	C₆₂H₁₁₃N₁₁O₁₂
Cas No.	59865-15-5
Smiles	[H][C@@]1([C@H](O)[C@H](C)CCCC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O)C(C)C
Relative Density.	1.012g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (49.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.8301 mL	4.1507 mL	8.3013 mL	41.5065 mL
5 mM	0.1660 mL	0.8301 mL	1.6603 mL	8.3013 mL
10 mM	0.0830 mL	0.4151 mL	0.8301 mL	4.1507 mL
20 mM	0.0415 mL	0.2075 mL	0.4151 mL	2.0753 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc