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Dihydrocyclosporin A

🥰Excellent
Catalog No. T31467Cas No. 59865-15-5
Alias Dihydrocyclosporin-A

Dihydrocyclosporin A (Dihydrocyclosporin-A) is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.

Dihydrocyclosporin A

Dihydrocyclosporin A

🥰Excellent
Purity: 99.50%
Catalog No. T31467Alias Dihydrocyclosporin-ACas No. 59865-15-5
Dihydrocyclosporin A (Dihydrocyclosporin-A) is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$129In StockIn Stock
5 mg$320In StockIn Stock
10 mg$470In StockIn Stock
25 mg$772In StockIn Stock
50 mg$1,080-In Stock
100 mg$1,460-In Stock
1 mL x 10 mM (in DMSO)$784In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.50%
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COA HNMR MS HPLC

Product Introduction

Bioactivity
Description
Dihydrocyclosporin A (Dihydrocyclosporin-A) is closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A significantly inhibits promastigotes and intracellular amastigotes.
Targets&IC50
Intracellular amastigotes:4.84 μM(48 h,L. donovani), Promastigotes:12.14(48 h,L. donovani), Intracellular amastigotes:5.23 μM(24 h,L. donovani), Promastigotes:21.24 μM(24 h,L. donovani)
In vitro
Dihydrocyclosporin A was able to inhibit the proliferation of L. donovani promastigotes (IC50: 21.24 μM and 12.14 μM at 24 h and 48 h, respectively) and intracellular amastigotes (IC50: 5.23 μM and 4.84 μM at 24 and 48 h, respectively) in vitro. Dihydrocyclosporin A caused several alterations in the morphology and ultrastructure of L. donovani, especially in the mitochondria. However, Dihydrocyclosporin A showed high cytotoxicity towards cells of the mouse macrophage cell line RAW264.7, with CC50 values of 7.98 μM (24 h) and 6.65 μM (48 h).[2].
SynonymsDihydrocyclosporin-A
Chemical Properties
Molecular Weight1204.63
FormulaC62H113N11O12
Cas No.59865-15-5
Smiles[H][C@@]1([C@H](O)[C@H](C)CCCC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O)C(C)C
Relative Density.1.012g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (49.81 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.8301 mL4.1507 mL8.3013 mL41.5065 mL
5 mM0.1660 mL0.8301 mL1.6603 mL8.3013 mL
10 mM0.0830 mL0.4151 mL0.8301 mL4.1507 mL
20 mM0.0415 mL0.2075 mL0.4151 mL2.0753 mL

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Keywords

Dihydrocyclosporin A
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