Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RIG012 is a potent RIG-I inhibitor with an IC50 value of 0.71 μM measured by NADH-coupled ATPase.RIG012 inhibited the expression of IFN-β and ISG hRsad2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 116.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 463.00 | |
25 mg | In stock | $ 763.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,380.00 | |
500 mg | In stock | $ 2,780.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 318.00 |
Description | RIG012 is a potent RIG-I inhibitor with an IC50 value of 0.71 μM measured by NADH-coupled ATPase.RIG012 inhibited the expression of IFN-β and ISG hRsad2. |
Targets&IC50 | RIG-I:0.71 μM |
In vitro |
RIG012 (1, 1.25, 1.5, 2, 2.5, 3, 4 μM) has potent dose-dependent inhibition of RIG-I signaling in HEK293T cells co-transfected with expression plasmids and reporter plasmids.[1] RIG012 (1.25, 2.25, 4.5, 9, 18 μM) has potent dose-dependent inhibition of IFN-β and ISG hRsad2 expression in A549 cells.[1] RIG012 contains a strong chromophore that absorbs in the visible range (λmax of 470 nm). Upon binding to RIG-I, the 470 nm absorption band of RIG012 undergoes a significant hyperchromic shift toward higher intensity values.[1] |
Molecular Weight | 359.42 |
Formula | C23H21NO3 |
CAS No. | 2642218-43-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (83.47 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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RIG012 2642218-43-5 Others inhibitor inhibit