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ML 209
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Catalog No. T37587Cas No. 1334526-14-5
ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM). ML-209 inhibits RORγt-dependent differentiation of isolated na?ve cord blood human CD4+T cells into Th17 T helper cells.
ML 209
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Purity: 99.87%
Catalog No. T37587Cas No. 1334526-14-5
ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM). ML-209 inhibits RORγt-dependent differentiation of isolated na?ve cord blood human CD4+T cells into Th17 T helper cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $93 | In Stock | In Stock | |
| 5 mg | $222 | In Stock | In Stock | |
| 10 mg | $289 | In Stock | In Stock | |
| 25 mg | $472 | In Stock | In Stock | |
| 50 mg | $687 | In Stock | In Stock | |
| 100 mg | $943 | In Stock | In Stock | |
| 500 mg | $1,880 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.87%
Appearance:Solid
Color:White
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Product Introduction
ML 209 AI Summary
ML 209 exhibits significant bioactivity as an antagonist of various receptors and impacts cell viability and protein stability across different contexts. It displaces fluorescein-labeled 25-hydroxycholesterol from human RORgammat LBD with IC50 values of 51.0 nM and 605.0 nM in a fluorescence polarization assay, and inhibits the transactivation domain of RORgammat in HEK293t cells with an IC50 of 300.0 nM. The compound also shows antagonist activity against TRbeta, TRalpha, LXRalpha, and ERRalpha with IC50 values of 13000.0 nM, 4500.0 nM, 10000.0 nM, and 14000.0 nM respectively in HEK293t cells. Additionally, in Drosophila Schneider cells, it acts as a RORgammat antagonist with an IC50 of 1100.0 nM.
In terms of cell viability, ML 209 has a varied impact. It shows a growth rate range from -0.14 to 0.81 in HEK293T cells, 0.9 to 0.96 in U2OS cells, and a broader range of -0.32 to 1.0 in human fibroblast cells, suggesting a complex relationship with cellular growth depending on the cell type.
Furthermore, in a Thermal Shift Assay, ML 209 influences the melting temperatures of various protein regions, indicating it impacts protein stability differently. It stabilizes some regions, such as M26-R383 (ΔTM = 1.0°C), S229-K512 (ΔTM = 4.29°C), P449-E759 (ΔTM = 0.97°C), M626-G740 (ΔTM = 1.95°C), and N44-E168 (ΔTM = 0.54°C). Conversely, it destabilizes the G861-E979 region (ΔTM = -3.38°C), highlighting its diverse interaction profile with protein domains..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM). ML-209 inhibits RORγt-dependent differentiation of isolated na?ve cord blood human CD4+T cells into Th17 T helper cells. |
| Targets&IC50 | RORγ:1.1 μM |
| Molecular Weight | 441.52 |
| Formula | C25H31NO6 |
| Cas No. | 1334526-14-5 |
| Smiles | C(CC(=O)N1C[C@@H](C)C[C@@H](C)C1)(C2=C(OC)C=C(OC)C=C2O)C=3C=C4C(=CC3)OCO4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 18.33 mg/mL (41.52 mM), Sonication is recommended.  | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 1.5 mg/mL (3.4 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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