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SAR7334

Name: SAR7334
Brand: TargetMol
SKU: T12849
Price: 65 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12849Cas No. 1333210-07-3

Alias TRCP6-IN-1

SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).

SAR7334

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Purity: 99.72%

Catalog No. T12849Alias TRCP6-IN-1Cas No. 1333210-07-3

SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$65	In Stock	In Stock
2 mg	$95	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$263	In Stock	In Stock
25 mg	$328	In Stock	In Stock
50 mg	$388	In Stock	In Stock
100 mg	$488	In Stock	In Stock
200 mg	$698	1-2 weeks	1-2 weeks
1 mL x 10 mM (in DMSO)	$178	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.72%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).
Targets&IC50	TRPC6:7.9 nM
In vitro	SAR7334 is an inhibitor of TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells(IC50s of 9.5, 282 and 226 nM)[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1].SAR7334 dose-dependently reduces TRPC6 currents (IC50 of 7.9 nM). SAR7334 (100 nM) substantially reduces TRPC6 currents[3].
In vivo	In isolated perfused lungs from mice, SAR7334 (10mg/kg, p.o.) inhibits TRPC6-dependent acute HPV . SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR)[3].
Synonyms	TRCP6-IN-1

Chemical Properties

Molecular Weight	367.87
Formula	C₂₁H₂₂ClN₃O
Cas No.	1333210-07-3
Smiles	N[C@@H]1CCCN(C1)[C@@H]1Cc2ccccc2[C@H]1Oc1ccc(cc1Cl)C#N
Relative Density.	1.30 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 350 mg/mL (951.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7184 mL	13.5918 mL	27.1835 mL	135.9176 mL
5 mM	0.5437 mL	2.7184 mL	5.4367 mL	27.1835 mL
10 mM	0.2718 mL	1.3592 mL	2.7184 mL	13.5918 mL
20 mM	0.1359 mL	0.6796 mL	1.3592 mL	6.7959 mL
50 mM	0.0544 mL	0.2718 mL	0.5437 mL	2.7184 mL
100 mM	0.0272 mL	0.1359 mL	0.2718 mL	1.3592 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc