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F13714 fumarate

Name: F13714 fumarate
Brand: TargetMol
SKU: T37622
Price: 413 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37622Cas No. 208109-39-1

Alias F 14679 fumarate

F13714 fumarate is a selective 5-HT1A receptor-biased agonist with antidepressant-like properties after a single dose in a mouse model of chronic mild stress.

F13714 fumarate

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Purity: 98.86%

Catalog No. T37622Alias F 14679 fumarateCas No. 208109-39-1

F13714 fumarate is a selective 5-HT1A receptor-biased agonist with antidepressant-like properties after a single dose in a mouse model of chronic mild stress.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$413	In Stock	In Stock
50 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.86%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	F13714 fumarate is a selective 5-HT1A receptor-biased agonist with antidepressant-like properties after a single dose in a mouse model of chronic mild stress.
In vitro	F13714 targets the 5-HT1A autoreceptor[1].
In vivo	METHODS: F13714 fumarate (1, 2, 4, 8, 16 mg/kg, oral) was administered to mice, and the antidepressant-like properties of the compound and its effects on cognitive function were evaluated using the forced swim test (FST) and novel object recognition (NOR), respectively; the depressive-like state was induced by the unpredictable chronic mild stress (UCMS) procedure to test the activity of F13714 fumarate in the depression model, and then sucrose preference, FST and locomotor activity were measured. The levels of phosphorylated cyclic AMP response element binding protein (p-CREB) and phosphorylated extracellular signal-regulated kinase (p-ERK1/2) were also determined. RESULTS: F13714 fumarate (2 and 4 mg/kg, p.o.) reduced immobility time in the FST, suggesting antidepressant-like properties in mice; F15599 did not disrupt long-term memory consolidation in the NOR at any dose tested, whereas F13714 fumarate impaired memory formation, especially at higher doses (4-16 mg/kg); F13714 fumarate rescued cortical and hippocampal deficits in p-ERK1/2 levels in UCMS mice, but did not affect p-CREB levels. [1]
Synonyms	F 14679 fumarate

Chemical Properties

Molecular Weight	538.97
Formula	C₂₅H₂₉ClF₂N₄O₅
Cas No.	208109-39-1
Smiles	C(=C/C(O)=O)\C(O)=O.C(=O)(N1CCC(CNCC=2N=C(NC)C(C)=CC2)(F)CC1)C3=CC(Cl)=C(F)C=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (371.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8554 mL	9.2770 mL	18.5539 mL	92.7695 mL
5 mM	0.3711 mL	1.8554 mL	3.7108 mL	18.5539 mL
10 mM	0.1855 mL	0.9277 mL	1.8554 mL	9.2770 mL
20 mM	0.0928 mL	0.4638 mL	0.9277 mL	4.6385 mL
50 mM	0.0371 mL	0.1855 mL	0.3711 mL	1.8554 mL
100 mM	0.0186 mL	0.0928 mL	0.1855 mL	0.9277 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc