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F13714 fumarate

Catalog No. T37622 CAS 208109-39-1

Synonyms: F13714 fumarate

F13714 fumarate, a selective biased agonist of the 5-HT1A receptor, exhibits antidepressant-like effects upon single administration in the mouse model of chronic mild stress[1].

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F13714 fumarate, CAS 208109-39-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 766.00
50 mg	6-8 weeks	$ 995.00
100 mg	6-8 weeks	$ 1,590.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	F13714 fumarate, a selective biased agonist of the 5-HT1A receptor, exhibits antidepressant-like effects upon single administration in the mouse model of chronic mild stress[1].
In vitro	F13714 targets 5-HT1A autoreceptors[1].
In vivo	In UCMS mice, F13714 administered at doses ranging from 4-16 mg/kg effectively alleviates depressive-like behavior as demonstrated in the forced swim test (FST), additionally restoring normal levels of p-ERK1/2 in the cortex and hippocampus without affecting p-CREB levels[1]. It significantly reduces immobility by 30.3% and 19.5% at 2 and 4 mg/kg doses, respectively[1]. At lower doses (0.5-2 mg/kg), F13714 distinctly and dose-dependently lowers rectal body temperature over a 2-hour period[1]. Moreover, at a dose of 2.5 mg/kg, it exhibits antidepressant and anxiolytic-like effects in naive rats[1].

Synonyms	F13714 fumarate
Molecular Weight	538.98
Formula	C25H29ClF2N4O5
CAS No.	208109-39-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (463.85 mM), Sonication is recommended.

References and Literature

1. Monika G?uch-Lutwin, et al. The selective 5-HT 1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress. Psychopharmacology (Berl). 2021 May 10.

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Keywords

F13714 fumarate 208109-39-1 F 13714 Fumarate F-13714 Fumarate F-13714 fumarate F13714 Fumarate inhibitor inhibit

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