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Cinnamtannin B-1
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Catalog No. T25253Cas No. 88082-60-4
Alias LDN-0022358, LDN0022358, LDN 0022358, Cinnamtannin B1 (constituent of cinnamomum verum bark)
Cinnamtannin B-1 (LDN 0022358) is an A-type proanthocyanidin contained in several plant species such as Vaccinium vitis-idaea, Laurus nobilis L., Cinnamomum zeylanicum, and Lindera umbellata. It is a potent antioxidant and protective agent against oxidative stress and apoptosis in human platelets. It is a Cox-2 inhibitor.
Cinnamtannin B-1
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Purity: 99.72%
Catalog No. T25253Alias LDN-0022358, LDN0022358, LDN 0022358, Cinnamtannin B1 (constituent of cinnamomum verum bark)Cas No. 88082-60-4
Cinnamtannin B-1 (LDN 0022358) is an A-type proanthocyanidin contained in several plant species such as Vaccinium vitis-idaea, Laurus nobilis L., Cinnamomum zeylanicum, and Lindera umbellata. It is a potent antioxidant and protective agent against oxidative stress and apoptosis in human platelets. It is a Cox-2 inhibitor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $84 | - | In Stock | |
| 5 mg | $213 | - | In Stock | |
| 10 mg | $343 | - | In Stock | |
| 25 mg | Inquiry | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.72%
Appearance:Solid
Color:Purple
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Product Introduction
Cinnamtannin B-1 AI Summary
Cinnamtannin B-1 exhibits notable bioactivities in several biological contexts. In HIV research, it shows significant anti-HIV activity with an IC50 greater than 25,000 nM and an EC50 of 21,000 nM in cell culture assays, boasting a therapeutic index greater than 1.2. It also inhibits HIV replication by 90% and HIV-reverse transcriptase activity by 13% at a concentration of 20 μg/mL. Additionally, Cinnamtannin B-1 affects platelet functions, such as thrombin-induced human platelet aggregation, with activities ranging from 71.8% to 81.9%, and influences microtubular reorganization and Btk activation. It demonstrates cytotoxicity against multiple human cell lines, with an ED50 value greater than 10.0 μg/mL for most, and an ED50 of 3.57 μg/mL against PRMI7951 cells. Although it shows weak inhibition of Bacillus stearothermophilus alpha glucosidase-4 with an IC50 greater than 100,000 nM, it effectively inhibits the COX2 enzyme in a dose-dependent manner, achieving 86% inhibition at 1,000 μg/mL. Moreover, it displays prominent antioxidant activity as a DPPH radical scavenger with an IC50 of 5.3 μg/mL. These diverse activities suggest potential therapeutic applications in antiviral, anticancer, and anti-inflammatory treatments, as well as in antioxidant therapies..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cinnamtannin B-1 (LDN 0022358) is an A-type proanthocyanidin contained in several plant species such as Vaccinium vitis-idaea, Laurus nobilis L., Cinnamomum zeylanicum, and Lindera umbellata. It is a potent antioxidant and protective agent against oxidative stress and apoptosis in human platelets. It is a Cox-2 inhibitor. |
| Synonyms | LDN-0022358, LDN0022358, LDN 0022358, Cinnamtannin B1 (constituent of cinnamomum verum bark) |
| Molecular Weight | 864.76 |
| Formula | C45H36O18 |
| Cas No. | 88082-60-4 |
| Smiles | [H][C@@]12[C@@H](O)[C@@](Oc3cc(O)cc(O)c13)(Oc1cc(O)c3[C@@H]([C@@H](O)[C@H](Oc3c21)c1ccc(O)c(O)c1)c1c(O)cc(O)c2C[C@@H](O)[C@H](Oc12)c1ccc(O)c(O)c1)c1ccc(O)c(O)c1 |
| Relative Density. | 1.789 g/cm3 (Predicted) |
| Storage | store at low temperature,keep away from direct sunlight,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Soluble |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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