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JX06

Name: JX06
Brand: TargetMol
SKU: T22350
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22350Cas No. 729-46-4

JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.

JX06

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Purity: 99.4%

Catalog No. T22350Cas No. 729-46-4

JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$135	In Stock	In Stock
50 mg	$218	In Stock	In Stock
100 mg	$353	In Stock	In Stock
200 mg	$523	-	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.4%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

JX06 AI Summary

JX06 exhibits a broad spectrum of bioactivities, demonstrating significant potency across various assays. It inhibits HIV-1 replication in a human T-cell line with an IC50 value of 0.52. Additionally, it inhibits human recombinant FAAH with an IC50 of approximately 79.4 µM and human MGL with an IC50 of 219 nM. The compound also shows over 50% inhibition of MGL activity at 10 µM. Beyond its antiviral activity, JX06 displays antifungal properties against Histoplasma capsulatum, with a minimum inhibitory concentration (MIC) of 40 µg/mL and efficacy in extending the survival of infected mice. Moreover, JX06 demonstrates antitrichomonas activity against Trichomonas vaginalis, with a MIC of 9.6 µM, and exhibits spermicidal activity with a minimum effective concentration of 0.1%. It also shows antifungal activity against several other fungi like Candida albicans and Cryptococcus neoformans with MIC values ranging from 38.4 µM to 76.9 µM. The compound inhibits pyruvate dehydrogenase kinases (PDKs) 1, 2, and 3, with IC50 values of 49 nM, and Ki values of 462 nM, 176 nM, and 2851 nM, respectively. It demonstrates antiproliferative effects on human A549 and Kelly cells, with IC50 values of 480 nM and 289 nM, respectively, and shows antitumor activity in A549 cell xenografts in mice. Additionally, it inhibits ALDH1A1 and ALDH2 with IC50 values of 40 nM and 1430 nM, respectively, and exhibits inhibitory effects on the SARS CoV-2 main protease (IC50 = 4030 nM) and human PHGDH (IC50 = 210 nM). JX06 also inhibits wild-type human liver FBPase by 26.08% at 10 µM. Overall, JX06 shows potential as a multi-target therapeutic agent with inhibitory activities across a range of biological targets, suggesting its applicability in treating various diseases and conditions, including infectious diseases, cancer, and metabolic disorders..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.
Targets&IC50	PDK1:49 nM (IC50), PDK3:313 nM (IC50), PDK2:101 nM (IC50)

Chemical Properties

Molecular Weight	324.51
Formula	C₁₀H₁₆N₂O₂S₄
Cas No.	729-46-4
Smiles	S=C(SSC(=S)N1CCOCC1)N1CCOCC1
Relative Density.	1.463g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (84.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0816 mL	15.4078 mL	30.8157 mL	154.0785 mL
5 mM	0.6163 mL	3.0816 mL	6.1631 mL	30.8157 mL
10 mM	0.3082 mL	1.5408 mL	3.0816 mL	15.4078 mL
20 mM	0.1541 mL	0.7704 mL	1.5408 mL	7.7039 mL
50 mM	0.0616 mL	0.3082 mL	0.6163 mL	3.0816 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc