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JX06

Name: JX06
Brand: TargetMol
SKU: T22350
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22350Cas No. 729-46-4

JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.

JX06

🥰Excellent

Purity: 99.4%

Catalog No. T22350Cas No. 729-46-4

JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$70	In Stock
25 mg	$162	In Stock
50 mg	$272	In Stock
100 mg	$455	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Batch Information

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Purity:99.4%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.
Targets&IC50	PDK3:313 nM (IC50), PDK1:49 nM (IC50), PDK2:101 nM (IC50)

Chemical Properties

Molecular Weight	324.51
Formula	C₁₀H₁₆N₂O₂S₄
Cas No.	729-46-4
Smiles	S=C(SSC(=S)N1CCOCC1)N1CCOCC1
Relative Density.	1.463g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (84.74 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0816 mL	15.4078 mL	30.8157 mL	154.0785 mL
5 mM	0.6163 mL	3.0816 mL	6.1631 mL	30.8157 mL
10 mM	0.3082 mL	1.5408 mL	3.0816 mL	15.4078 mL
20 mM	0.1541 mL	0.7704 mL	1.5408 mL	7.7039 mL
50 mM	0.0616 mL	0.3082 mL	0.6163 mL	3.0816 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc