Shopping Cart

Your shopping cart is currently empty

Bepridil hydrochloride

Name: Bepridil hydrochloride
Brand: TargetMol
SKU: T5391
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5391Cas No. 68099-86-5

Alias CERM 1978

Bepridil hydrochloride (CERM 1978) is a calcium channel blocker that also inhibits Na+/Ca2+ exchange (NCX), sodium channels, and cardiac sarcolemmal KATP channels.

Bepridil hydrochloride

🥰Excellent

Purity: 99.68%

Catalog No. T5391Alias CERM 1978Cas No. 68099-86-5

Bepridil hydrochloride (CERM 1978) is a calcium channel blocker that also inhibits Na+/Ca2+ exchange (NCX), sodium channels, and cardiac sarcolemmal KATP channels.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$40	In Stock	In Stock
25 mg	$81	In Stock	In Stock
50 mg	$113	In Stock	In Stock
100 mg	$163	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.68%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Bepridil hydrochloride (CERM 1978) is a calcium channel blocker that also inhibits Na+/Ca2+ exchange (NCX), sodium channels, and cardiac sarcolemmal KATP channels.
In vitro	Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM [2].
In vivo	The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered [1].
Synonyms	CERM 1978

Chemical Properties

Molecular Weight	403
Formula	C₂₄H₃₅ClN₂O
Cas No.	68099-86-5
Smiles	Cl.CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1
Relative Density.	1.054g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (322.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4814 mL	12.4069 mL	24.8139 mL	124.0695 mL
5 mM	0.4963 mL	2.4814 mL	4.9628 mL	24.8139 mL
10 mM	0.2481 mL	1.2407 mL	2.4814 mL	12.4069 mL
20 mM	0.1241 mL	0.6203 mL	1.2407 mL	6.2035 mL
50 mM	0.0496 mL	0.2481 mL	0.4963 mL	2.4814 mL
100 mM	0.0248 mL	0.1241 mL	0.2481 mL	1.2407 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc