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Bepridil hydrochloride

Name: Bepridil hydrochloride
Brand: TargetMol
SKU: T5391
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5391Cas No. 68099-86-5

Alias CERM 1978

Bepridil hydrochloride (CERM 1978) is a calcium channel blocker that also inhibits Na+/Ca2+ exchange (NCX), sodium channels, and cardiac sarcolemmal KATP channels.

Bepridil hydrochloride

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Purity: 99.68%

Catalog No. T5391Alias CERM 1978Cas No. 68099-86-5

Bepridil hydrochloride (CERM 1978) is a calcium channel blocker that also inhibits Na+/Ca2+ exchange (NCX), sodium channels, and cardiac sarcolemmal KATP channels.

Pack Size	Price	Availability
5 mg	$30	In Stock
10 mg	$42	In Stock
25 mg	$85	In Stock
50 mg	$118	In Stock
100 mg	$172	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

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Purity:99.68%

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Bepridil hydrochloride (CERM 1978) is a calcium channel blocker that also inhibits Na+/Ca2+ exchange (NCX), sodium channels, and cardiac sarcolemmal KATP channels.
In vitro	Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM [2].
In vivo	The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered [1].
Synonyms	CERM 1978

Chemical Properties

Molecular Weight	403
Formula	C₂₄H₃₅ClN₂O
Cas No.	68099-86-5
Smiles	Cl.CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1
Relative Density.	1.054g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (322.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4814 mL	12.4069 mL	24.8139 mL	124.0695 mL
5 mM	0.4963 mL	2.4814 mL	4.9628 mL	24.8139 mL
10 mM	0.2481 mL	1.2407 mL	2.4814 mL	12.4069 mL
20 mM	0.1241 mL	0.6203 mL	1.2407 mL	6.2035 mL
50 mM	0.0496 mL	0.2481 mL	0.4963 mL	2.4814 mL
100 mM	0.0248 mL	0.1241 mL	0.2481 mL	1.2407 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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