Pipoxazole (COR-32-24) is an adrenergic receptor agonist that can be used to study depression.

Fixed small doses of radiolabeled COR3224 (14C)COR3224, 0.06 pM) were used for brain uptake assessment in rats and different concentrations of unlabeled COR3224 (5, 10, 20, and 40 μM) were added to the injection mixture by rapid intracarotid injection technique, COR3224 showed concentration-dependent brain uptake properties, indicating the existence of a carrier-mediated transport mechanism for carrier-mediated transport mechanism across the blood-brain barrier (BBB). The brain uptake index (BUI) of labeled COR3224 gradually decreased from 10.15% to approximately 5.4% as the concentration of unlabeled COR3224 increased. [1];Adult male rats (250-300gr, Sprague Dawley) were orally administered 10, 40, and 160 mg/kg radiolabeled 14C-COR3224 (30 microCi/kg) in aqueous solution and after 0.25; 0.5; 0.75; 1; 2; 4; 6; 8; 12; 16; 24; and 30 hr (5 doses of rats per session ) when sacrificed. A linear relationship was found between AUC and the doses used for TR and UP plasma assays. In contrast, brain AUC for TR and U.P was not proportional to dose, and the evolution of brain/plasma concentration ratios showed higher values for the 10 mg/kg dose than for the 40 and 160 mg/kg doses. [4]